Zheng Lili,Wang Jinhu,Lv Danni,et al.Prevention and control strategies of diagnosing and treating pediatric solid tumors during the epidemic period of SARS-CoV-2[J].Journal of Clinical Pediatric Surgery,,19():104-110.[doi:10.3969/j.issn.1671-6353.2020.02.003]
Prevention and control strategies of diagnosing and treating pediatric solid tumors during the epidemic period of SARS-CoV-2
- Keywords:
- Pediatric Solid Tumor; SARS-CoV-2; COVID-19; Control Strategy; Child
- CLC:
- R730.5;R473.51;R563.1;R613;R608
- Abstract:
- A novel coronavirus infection (corona virus disease 2019,COVID-19) occurred in Hubei Province in December 2019. It has gradually spread to various parts of China and overseas countries. Recently International Committee on Taxonomy of Viruses (ICTV) renamed the pathogenic virus as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the susceptible population is made up of children and pregnant women. At one hand,children with malignant solid tumors tend to have lower immunity than normal counterparts due to the effects of tumors and such comprehensive treatments as chemoradiotherapy and immunotherapy. As a result,they may be more prone to infections and severe complications. At the other hand,the continuity and standardization of comprehensive treatments is crucial for achieving a decent prognosis. How to prevent and control the epidemic and ensure the orderly flows of cancer diagnosis and treatment at the same time have presented huge challenges for both patients and clinicians during the epidemic period. Based upon the transmission characteristics of SARS-CoV-2 and the requirements for prevention and control of COVID-19,the authors proposed some concrete measures and practical strategies of managing pediatric solid tumors during the epidemic period. The specific measures include:1)Establishing a reasonable management system for outpatients and inpatients of solid tumors,2)Performing emergency surgery,rationally handling limited-term procedures and appropriately postponing elective surgery,3)Implementing regular chemotherapy. All the above measures are taken for protecting children from SARS-CoV-2 infection and ensuring the continuity of comprehensive treatments of pediatric solid tumors.
References:
1 Zhu N,Zhang D,Wang W,et al.A novel coronavirus from patients with pneumonia in China,2019[J].N Engl J Med,2020.DOI:10.1056/NEJMoa2001017.
2 World Health Organization.Laboratory testing for 2019 novel coronavirus (2019-nCoV) in suspected human cases[EB/OL].(2020-1-23)[2020-02-02].https://www.who.int/health-topics/coronavirus/laboratory-diagnostics-for-novel-coronavirus.pdf.
3 Li Q,Guan X,Wu P,et al.Early transmission dynamics in Wuhan,China,of novel coronavirus-infected pneumonia[J].N Engl J Med,2020.DOI:10.1056/NEJMoa2001316.
4 Huang C,Wang Y,Li X,et al.Clinical features of patients infected with 2019 novel coronavirus in Wuhan,China[J].Lancet,2020.DOI:10.1016/S0140-6736(20)30183-5.
5 中华人民共和国国家卫生健康委员会.新型冠状病毒感染的肺炎诊疗方案(试行第五版)[EB/OL].(2020-02-04)[2020-02-05].http://www.nhc.gov.cn/xcs/zhengcwj/202001/4294563ed35b43209b31739bd0785e67/files/7a9309111267475a99d4306962c8bf78.pdf. National Health Commission of PRC:Diagnostic and Therapeutic Protocols for Novel Coronavirus-Infected Pneumonia (Interim V Edition).[EB/OL].(2020-02-04)[2020-02-05].http://www.nhc.gov.cn/xcs/zhengcwj/202001/4294563ed35b43209b31739bd0785e67/files/7a9309111267475a99d4306962c8bf78.pdf.
6 中华医学会儿科学分会,中华儿科杂志编辑委员会.儿童2019新型冠状病毒感染的诊断与防治建议(试行第一版)[J].中华儿科杂志,2020,58(00):E004-E004.DOI:10.3760/cma.j.issn.0578-1310.2020.0004. Branch of Pediatrics,Chinese Medical Association,Editorial Board of Chinese Journal of Pediatrics.Recommendations for the Diagnosis,Prevention and Control of 2019 Novel Coronavirus Infection in Children (First Interim Edition)[J].Chin J Pediatr,2020,58(00):E004-E004.DOI:10.3760/cma.j.issn.0578-1310.2020.0004.
7 中国疾病预防控制中心新型冠状病毒肺炎应急响应机制流行病学组.新型冠状病毒肺炎流行病学特征分析[J].中华流行病学杂志,2020,41(2):145-151.DOI:10.3760/cma.j.issn.0254-6450.2020.02.003. Emergency Response Epidemiology Team of Novel Coronavirus Pneumonia:epidemiological characteristics of an outbreak of 2019 novel coronavirus diseases (COVID-19) in China[J].Chin J Epidemiol,2020,41(2):145-151.DOI:10.3760/cma.j.issn.0254-6450.2020.02.003.
8 周莎,潘淑华,徐鋈.2014—2018年某院儿童血液肿瘤患者医院感染现患率调查[J].中国感染控制杂志,2019,18(11):1044-1048.DOI:10.12138/j.issn.1671-9638.20195259. Zhou S,Pan SH,Xu Y.Prevalence of healthcare-associated infection in children with hematological tumor at a hospital from 2014 to 2018[J].Chin J Infect Control,2019,18(11):1044-1048.DOI:10.12138/j.issn.1671-9638.20195259.
9 张月华,林道炯,肖美芳,等.三月龄婴儿新型冠状病毒感染一例[J] .中华儿科杂志,2020,58.DOI: 10.3760/cma.j.issn.0578-1310.2020.0006. Zhang YH,Lin DJ,Xiao MF,et al.2019-novel coronavirus infection in a 3-month-old baby:one case report[J].Chin J Pediatr,2020,58.DOI: 10.3760/cma.j.issn.0578-1310.2020.0006..
10 陈志敏,傅君芬,舒强,等.儿童19冠状病毒疾病(COVID-19)诊疗指南(第二版)[J].浙江大学学报(医学版),2020,49(1):1-8.DOI:10.3785/j.issn.1008-9292.2020.02.01. Chen ZM,Fu JF,Shu Q,et al.Diagnostic and Therapeutic Guidelines of Pediatric COVID-19 (Second Edition)[J].Journal of Zhejiang University (Medical Sciences),2020,49(1):1-8.DOI:10.3785/j.issn.1008-9292.2020.02.01.
11 中华人民共和国卫生健康委员会.医疗机构内新型冠状病毒感染预防与控制技术指南(第一版) [EB/OL].(2020-01-21)[2020-01-22].http://www.nhc.gov.cn/yzygj/s7659/202001/b91fdab7c304431eb082d67847d27e14.shtml. National Health Commission of PRC:Technique Guidelines of Preventing and Controlling Novel Coronavirus Infection within Healthcare Institutions (First Edition) [EB/OL].(2020-01-21)[2020-01-22].http://www.nhc.gov.cn/yzygj/s7659/202001/b91fdab7c304431eb082d67847d27e14.shtml.
12 中华人民共和国卫生健康委员会.新型冠状病毒感染的肺炎防护中常见医用防护使用范围指引(试行)[EB/OL].(2020-01-26)[2020-01-27].http://www.nhc.gov.cn/yzygj/s7659/202001/e71c5de925a64eafbe1ce790debab5c6.shtml. National Health Commission of PRC:Guidance on Application Scopes of Common Protections for Novel Coronavirus-Infected Pneumonia (Interim)[EB/OL].(2020-01-26)[2020-01-27].http://www.nhc.gov.cn/yzygj/s7659/202001/e71c5de925a64eafbe1ce790debab5c6.shtml.
13 中华人民共和国卫生部.医院空气净化管理规范(WS/T 368-2016).[EB/OL].(2012-04-05)[2020-02-02].http://www.nhc.gov.cn/wjw/s9496/201204/54511.shtml. National Health Commission of PRC:Management Standards of Air Purification at Hospitals (WS/T 368-2016).[EB/OL].(2012-04-05)[2020-02-02].http://www.nhc.gov.cn/wjw/s9496/201204/54511.shtml.
14 中华人民共和国卫生部.医疗机构消毒技术规范(WS/T367-2012)[EB/OL].(2012-04-05)[2020-02-02].http://www.nhc.gov.cn/wjw/s9496/201204/54510/fil-es/2c7560199b9d42d7b4fce28eed1b7be0.PDF. National Health Commission of PRC:Standards of Disinfection Techniques at Healthcare Institutions (WS/T367-2012)[EB/OL].(2012-04-05)[2020-02-02].http://www.nhc.gov.cn/wjw/s9496/201204/54510/files/2c7560199b9d42d7b4fce28eed1b7be0.PDF.
15 中华人民共和国国务院令(第380号)——医疗废物管理条例[EB/OL].(2003-06-16) [2020-02-02].http://www.gov.cn/banshi/2005-08/02/content_19238.htm. Decree No.380 of National Health Commission of PRC:Management Clauses of Medical Wastes[EB/OL].(2003-06-16)[2020-02-02].http://www.gov.cn/banshi/2005-08/02/content_19238.htm
16 中华人民共和国卫生部令第36号——医疗卫生机构医疗废物管理办法[EB/OL].(2003-10-15)[2020-02-02].http://www.gov.cn/gongbao/content/2004/content_62768.htm Decree No.36 of National Health Commission of PRC:Management Measures of Medical Wastes at Healthcare Institutions [EB/OL].(2003-10-15)[2020-02-02].http://www.gov.cn/gongbao/content/2004/content_62768.htm.
17 国家卫生健康委办公厅关于做好新型冠状病毒感染的肺炎疫情期间医疗机构医疗废物管理工作的通知[EB/OL].(2020-01-28)[2020-02-02].http://www.nhc.gov.cn/yzygj/s7659/202001/6b7bc23a44624ab2846b127d146be758.shtml. General Office of National Health Commission’s Notice on Properly Managing Medical Wastes at Healthcare Institutions during the Epidemic Period of Novel Coronavirus-Infected Pneumonia [EB/OL].(2020-01-28)[2020-02-02].http://www.nhc.gov.cn/yzygj/s7659/202001/6b7bc23a44624ab2846b127d146be758.shtml.
18 吴春星,宁波,王达辉,等.严重急性呼吸综合征冠状病毒2流行期间小儿骨科门急诊及住院手术感染防控建议[J/OL].临床小儿外科杂志,(2020-02-18) [2020-02-18] https://mp.weixin.qq.com/s/z_Wl0aYHRNZcRm4yO7_dZA. Wu CX,Ning B,Wang DH,et al.Surgical infection control recommendations at pediatric orthopedic outpatient and emergency clinics and inpatient wards during the epidemic period of severe acute respiratory syndrome coronavirus 2[J/OL].J Clin Ped Sur,(2020-02-18)[2020-02-18]https://mp.weixin.qq.com/s/z_Wl0aYHRNZcRm4yO7_dZA.
Memo
收稿日期:2020-02-20。
基金项目:浙江大学新型冠状病毒肺炎（COVID-19）应急科研专项资金资助
通讯作者:王金湖,Email:wjh@zju.edu.cn