Wang Changfeng,Sun Jiali,Wu Changhua,et al.Curative efficacy of timolol plus 595nm pulsed dye laser for superficial infantile hemangioma[J].Journal of Clinical Pediatric Surgery,,18():953-958.[doi:10.3969/j.issn.1671—6353.2019.11.011]
Curative efficacy of timolol plus 595nm pulsed dye laser for superficial infantile hemangioma
- Keywords:
- Hemangioma; Lasers; Timolol; Treatment Outcome; Infant
- CLC:
- R543;R318.51
- Abstract:
- Objective To explore the curative efficacy of 595nm pulsed dye laser plus 0.5% timolol for superficial infantile hemangiomas.Methods From June 2018 to June 2019,a total of 156 hemangioma children were recruited and divided into three groups of pulsed dye laser (n=64),external timolol (n=60) and combination treatment (n=32).Three groups were reviewed monthly and tumor changes monitored by photograph and ultrasound.Four levels of efficacy evaluations were assigned and the data of gender,lesion size/location,treatment frequency,curative rate and adverse reactions recorded.The treatment outcomes of three groups were compared.Results The effective rate of combination treatment group (96.9%,31/32) was not statistically different from those of pulsed dye laser group (95.3%,61/64) and timolol group (95%,57/60).As compared with pulsed dye laser (29.7%,19/64) and timolol groups (18.3%,11/60),the efficacy of combination treatment (56.3%,18/32) was more inclined to level 4 (P<0.05).The time to reach grade 4 treatment in combination treatment group was (3.3±0.21) months and it was significantly lower than that in either treatment group alone (P<0.05).No serious complications occurred in three groups.Conclusion Curative efficacy of timolol plus 595nm pulsed dye laser is superior to that of simple application of timolol or 595nm pulsed dye laser alone.
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Memo
收稿日期:2019-08-01。
基金项目:济南市卫生和计划生育委员会科技计划项目（编号：2016-1-16）
通讯作者:郭磊,Email:1045264128@qq.com