Wei Nannan,Su Yanwei,Rong Zhihui,et al.Efficacy of traditional Chinese medicine “intestinal adhesion prescription” for neonatal intestinal diseases[J].Journal of Clinical Pediatric Surgery,,18():664-669.[doi:10.3969/j.issn.1671-6353.2019.08.010]
Efficacy of traditional Chinese medicine “intestinal adhesion prescription” for neonatal intestinal diseases
- CLC:
- R289.5;R656.9
- Abstract:
- Objective To evaluate the efficacy of Chinese herbal medicine prescription Intestinal Adhesion Prescription (IAP) for surgery and conservative treatment of neonatal intestinal diseases and discuss its mechanism in the treatment of neonatal intestinal diseases.Methods From January 1,2012 to January 1,2017,41 neonates with intestinal diseases were retrospectively analyzed.Thirty neonates with postoperative intestinal ileus after abdominal surgery were enrolled into operative group while another 14 cases received IAP plus food fasting and gastrointestinal decompression.And 16 cases received conventional treatment without IAP.In non-operative Group,11 neonates of early-stage necrotizing enterocolitis (NEC) presented vomiting,repeated abdominal distension after feeding,hematochezia and heightened inflammation.In this control group,5 cases received IAP while the remainders were treated routinely.Symptoms of intestinal obstruction and recovery of digestive tract function were analyzed after oral intake of IAP.Results In operative group,the duration from intestinal obstruction to total enteral feedingwas (10.6±0.7) and (12.8±0.6) days in IAP and control groups respectively.There were significant statistical differences (t=2.23,P=0.03).In two groups,the re-operative rate was 7.1%(1/14) and 25%(4/16) and the mortality rate 7.1%(1/14) and 18.8%(3/16) respectively.In non-operative group,all 5 IAP-treated patients had a negative conversion of fecal occult blood with lower inflammatory parameters.There was no sign of intestinal perforation,hematochezia or sign of peritonitis after withdrawing or degrading antibiotics.In control group,2 cases of intestinal perforation were operated while another 2 cases died and 2 recovering children were discharged.The duration from intestinal obstruction to total enteral feedingwas (17.4±2.5) days and (29.5±0.5) days in IAP and control groups respectively.Conclusion Chinese herbal medicine prescription IAP not only has marked efficacy for patients with postoperative adhesive intestinal obstruction after neonatal surgery.It is also both safe and effective for early-stage NEC.
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Memo
收稿日期:2017-11-22。
基金项目:国家自然科学基金青年项目（编号：81401240）；国家自然科学基金青年项目（编号：81601330）
通讯作者:杨继鑫,Email:yangjixin0910@126.com