Chen Zheng,Fu Chujie,Peng Tuochao,et al.Analgesia of nabulphine hydrochloride after closed reduction and Kirschner wire internal fixation of ulnar and radius fractures in children[J].Journal of Clinical Pediatric Surgery,,18():503-507.[doi:10.3969/j.issn.1671-6353.2019.06.013]
Analgesia of nabulphine hydrochloride after closed reduction and Kirschner wire internal fixation of ulnar and radius fractures in children
- Keywords:
- Nabuphine; Ulna Fractrues; Radius Fractrues; Analgesia
- CLC:
- R726.8;R614.2+4;R971+.1
- Abstract:
- Objective To compare the analgesic efficacies and adverse reactions of nabulphine hydrochloride and sufentanil on children after orthopedic surgery and explore the safety and effectiveness of nabulphine during postoperative analgesia. Methods A total of 60 hospitalized children from September 2017 to August 2018 undergoing Kirschner wire internal fixation plus closed reduction of radius and ulnar bone were selected as study subjects.They were divided into nabulphine hydrochloride group (n=30) and sufentanil group (n=30) according to different anesthetics.The analgesic and sedative effects and the incidence of postoperative respiratory depression,nausea,vomiting and pruritus were evaluated.Results The preoperative FLACC scores of two groups were (1.56±0.32) and (1.54±0.41) respectively.And there was no statistically significant inter-group difference (t=1.12,P=0.41).No statistically significant postoperative difference existed in FLACC scores at 0.5,6,12 and 24 h (P>0.05).No statistically significant inter-group difference existed in postoperative Ramsay scores at 0.5,6,12 and 24 h (P>0.05).The postoperative incidence of respiratory inhibition,nausea,vomiting and pruritus was statistically significant in nabphine hydrochloride group (P<0.05). Conclusion As compared with sufentanil,nalbuphine hydrochloride is more suitable for postoperative analgesia in children undergoing moderately painful surgery.
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Memo
收稿日期:2018-11-08。
基金项目:湖南省科学技术厅临床医疗技术创新引导计划（编号：2018SK50407）
通讯作者:屈双权,Email:qushuangquan1974@163.com