Xiong Xiqian,Zhan Jianghua,Yu Chen,et al. Relationship between native liver survival and ductular reaction in biliary atresia.[J].Journal of Clinical Pediatric Surgery,,17():814-820.
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 Relationship between native liver survival and ductular reaction in biliary atresia.

Journal of Clinical Pediatric Surgery[ISSN:1671-6353/CN:43-1380/R] volume: 第17卷 Number: 2018 11 Page: 814-820 Column: 专题讨论 Date of publication: 2018-11-20
Author(s):
 Xiong Xiqian1; Zhan Jianghua2; Yu Chen1; Hu Xiaoli3; Zhao Linsheng3.
 1.Graduate School,Tianjin Medical University,Tianjin 300070,China;
Keywords:
 ; Biliary Atresia;  Native Liver Survival;  Ductular Reaction;  Immunohistochemistry;  Research
Document code:
A
Abstract:
 ObjectiveTo explore the relationship between ductular reaction in liver biopsy during Kasai and native liver survival of biliary atresia (BA).MethodsThe cases of BA were selected for time of native liver survival over 5 years after Kasai and nonsevere enough for diagnosing (BAA,n=10) and time of native liver survival under 1 year after Kasai (BAB,n=10),choledochal cyst (CC,n=10),cholestasis (CS,n=10) and autopsy (n=10).HE and CK7,CK19,CD56,EpCAM immunohistochemical staining methods were employed for scoring the pathological indices of four groups and calculating the AOD of four proteins.And the relationship was analyzed between native liver survival and ductular reaction in BA.ResultsThe degrees of hepatic fibrosis,bile duct hyperplasia and bile embolus score in BA group were higher than those in three control groups and the differences were statistically significant(H=24.208,P<0.05; H=39.779,P<0.05; H=23.119,P<0.05);They are significant differences expression of CK7,CK19,CD56 and EpCAM in liver tissues of BA,CC,CS and control group and the expression of BA group was significantly greater than control groups (F=111.184,P<0.05;F=1064.972,P<0.05;F=79.054,P<0.05;F=53.858,P<0.05).The expressions of CK7,CD56 and EpCAM in good prognosis group of BA were significantly lower than those of poor prognosis group (t=12.686,P<0.05;t=9.517,P<0.05;t=5.232,P<0.05).ConclusionLiver histopathology scores may be used in the differential diagnosis of BA and other obstructive jaundice.Ductular reaction in liver biopsy during Kasai is closely correlated with native liver survival of BA.And CK7,CD56 and EpCAM proteins may be used as prognostic indicators of BA.The lower expressions,the longer survival time of autologous liver.
Last Update: 2018-11-23