Gu Song,Gu Hongbin,Ma Jin,et al.Experimental treatment of esophageal stricture with biodegradable magnesium alloy stent.[J].Journal of Clinical Pediatric Surgery,,17():60-65.
Experimental treatment of esophageal stricture with biodegradable magnesium alloy stent.
Journal of Clinical Pediatric Surgery[ISSN:1671-6353/CN:43-1380/R]
volume:
第17卷
Number:
2018 01
Page:
60-65
Column:
临床研究
Date of publication:
2018-01-28
- Keywords:
- Esophagus; Stents; Esophageal Stenosis; Animals; Laboratory
- Document code:
- A
- Abstract:
- ObjectiveTo explore the feasibility of biodegradable magnesium alloy stent in the treatment of esophageal stenosis. Methods The model of esophageal stenosis was established and magnesium alloy stents were placed in esophageal stenosis in 4 rabbits by balloon catheter dilation.Their mental,behavioral,dietary,physiological and biochemical profiles were recorded.And the pathological changes of esophagus,liver and kidney and the improvement of esophageal stenosis were evaluated. Results The animal model of esophageal stenosis was successfully established by sodium hydroxide chemical cauterization.Four radiolabeled magnesium alloy stents were placed in situ and radioactive marker observed in 3/4 rabbits at Week 12 poststenting.Food intake improved significantly after stenting.No obvious changes occurred in mental,behavioral and blood biochemical parameters.Hematoxylin & eosin staining showed that the esophageal mucosa was complete,there was a submucosal infiltration of inflammatory cells and macrophages infiltrated and liver and kidney showed no obvious change. Conclusion With the advantages of high safety and minimal adverse reaction,the above stent is effective for esophageal stenosis and it has great potentials for clinical application.
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