References:

1 Drescher W.Schlieper G.Floege J.et al.Steroid-related osteonecrosis-an update[J]. Nephrol Dial Transplant, 2011,26(9):272 8— 2731. 2Kim EH, Sohn S, Kwon HJ, et al. Sodium selenite induces superoxide-mediated mitochondrial damage and subsequent autophagic cell death in malignant glioma cells[J]. Cancer Res,2007,67(13):631 4— 6324. 3Junjing Jia, Wei Yao, Min Guan, et al. Glucocorticoid dose determines osteocyte cell fate[J]. FASEB, 2011,25(10):336 6— 3376. 4Youm YS,Lee SY,Lee SH. Apoptosis in the Osteonecrosis of the Femoral Head[J].Clin Orthop Surg,2010,2(4):250 — 255. 5Glimcher MJ, Kenzora JE. The biology of osteonecrosis of the human femoral head and its clinical implications. III. Discussion of the etiology and genesis of the pathological sequelae: commments on treatment[J]. Clin Orthop Relat Res, 1979,(140):27 3— 312. 6Calder JD, Buttery L, Revell PA, et al.Apoptosis: a significant cause of bone cell death in osteonecrosis of the femoral head[J]. J Bone Joint Surg Br, 2004,86(8):120 9— 1213. 7Weinstein RS, Nicholas RW, Manolagas SC. Apoptosis of osteocytes in glucocorticoid-induced osteonecrosis of the hip [J]. Clin Endocrinol Metab,2000,85(8):290 7— 2912. 8Jones LC, Hungerford DS. The pathogenesis of osteonecrosis[J]. Instr Course Lect, 2007,56:17 9— 196. 9Kerachian MA, Harvey EJ, Cournoyer D, et al. A rat model of early stage osteonecrosis induced by glucocorticoids[J].J Orthop Surg Res, 2011,6:62. 10Moriishi T, Maruyama Z, Fukuyama R, et al.Overexpression of Bcl 2in osteoblasts inhibits osteoblast differentiation and induces osteocyte apoptosis[J].PLoS One,2011,6(11):e27487. 11Al-Dujaili SA, Lau E, Al-Dujaili H, et al. Apoptotic osteocytes regulate osteoclast precursor recruitment and differentiation in vitro[J]. J Cell Biochem,2011,112(9):241 2— 2423. 1 2Powell C, Chang C, Gershwin ME, et al. Current Concepts on the Pathogenesis and Natural History of Steroid-Induced Osteonecrosis[J]. Clinic Rev Allerg Immunol, 2011,41(1):10 2— 113. 1 3Weinstein RS, Chen JR, Powers CC, et al. Promotion of osteoclast survival and antagonism of bisphosphonate-induced osteoclast apoptosis by glucocorticoids[J]. J Clin Invest, 2002,109(8):1041 — 1048. 1 4Weinstein RS, O’Brien CA, Almeida M, et al.Osteoprotegerin prevents glucocorticoid-induced osteocyte apoptosis in mice[J].Endocrinology,2011,152(9):332 3— 3331. 1 5韦宜山,刘万林,丁良甲,等.发育性髋脱位髋臼软骨细胞凋亡的实验研究[J]. 临床小儿外科杂志, 2012,11(4):27 7— 281. 1 6O. Kepp L, Galluzzi M, Lipinski J, et al. Cell death assays for drug discovery[J].Nature Reviews Drug Discovery, 2011,10(3):221 — 237. 1 7Rabinowitz JD, White E.Autophagy and metabolism[J].Science,2010,330(6009): 134 4— 1348. 1 8Levine B, Mizushima N, Virgin HW. Autophagy in immunity and inflammation[J]. Nature, 2011,469(7330): 32 3— 335. 1 9Lai EH, Hong CY, Kok SH, et al. Simvastatin alleviates the progression of periapical lesions by modulating autophagy and apoptosis in osteoblasts[J]. J Endod,2012,38(6):75 7— 763. 20 Whitehouse CA,Waters S, Marchbank K, et al.Neighbor of Brca1 gene(Nbr1)functions as a negative regulator of postnatal osteoblastic bone formation and p3 8MAPK activity[J]. Proc Natl Acad Sci U S A, 2010,107(29):1291 3— 12918. 21 Zhao Y, Chen G, Zhang W, et al. Autophagy regulates hypoxia-induced osteoclastogenesis through the HIF-1α/BNIP 3signaling pathway[J]. J Cell Physiol, 2012,227(2):63 9— 648. 2 2Hidemi Rikiishi. Novel Insights into the Interplay between Apoptosis and Autophagy[J].Int J Cell Biol, 2012, Article ID 317645, 14. 2 3Yousefi S, Perozzo R, Schmid I, et al. Calpain-mediated cleavage of Atg 5switches autophagy to apoptosis[J].Nature Cell Biology, 2006,8(10):112 4— 1132. 2 4Djavaheri-Mergny M,Maiuri MC,Kroemer G.Cross talk between apoptosis and autophagy by caspase-mediated cleavage of Beclin 1[J].Oncogene,2010,29(12):171 7— 1719. 2 5Li H, Wang P, Sun Q, et al. Following cytochrome c release, autophagy is inhibited during chemotherapy-induced apoptosis by caspase 8-mediated cleavage of beclin 1[J]. Cancer Research, 2011,71(10):362 5— 3634. 2 6Wei Y,Sinha S, Levine B. Dual role of JNK1-mediated phosphorylation of Bcl- 2in autophagy and apoptosis regulation[J].Autophagy, 2008,4(7):94 9— 951. 2 7Green DR, Kroemer G. Cytoplasmic functions of the tumour suppressor p53[J]. Nature,2009,458(7242):112 7— 1130. 2 8Budanov AV, Karin M. p5 3target genes sestrin1 and sestrin 2connect genotoxic stress and mTOR signaling[J].Cell, 2008,134(3):451 — 460.