GU Tao,LU Hong-ting,DONG Qian.The relationship between Kai1/CD82 expression and metastasis of neuroblastoma[J].Journal of Clinical Pediatric Surgery,,12():100-102.[doi:10.3969/j.issn.1671— 6353.2013.02.007]
The relationship between Kai1/CD82 expression and metastasis of neuroblastoma
- Keywords:
- Neuroblastoma; Tumor Suppressor Genes; Kai1/CD82
- Abstract:
- Objetive To investigate the relationship between Kai1 / CD82 expression and metastasis of neuroblastoma. Methods RT-PCR shall be applied to test the expression of Kai1mRNA in 40 neuroblastoma paraffin specimens of each period.Kai1/CD82 level was measured by immunohistochemistry method in 40 neuroblastoma paraffin specimens of each period. Results RT-PCR shows that the relative content of Kai1mRNA in in the neuroblastoma group with lymph node or distant metastasis is 0.0748±0.0063,the relative content of Kai1mRNA in the neuroblastoma group without metastasis is 0.75±0.03, there is statistical significance in the two group difference.The positive rate of Kai1/CD82 expression was 71.43% in the neuroblastoma group without metastasis and 31.58% in the neuroblastoma group with lymph node or distant metastasis. There was a significant difference in the Kai1/CD82 expression between neuroblastoma groups with and without metastasis. There was no significant differences in the Kai1/CD82 expression between metastasis neuroblastoma groups with and without bone marrow infiltration. Conclusions The expression level of Kai1/CD82 can be used as a potential predictor of metastasis of neuroblastoma.
References:
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