Shi Xiaofeng,Du Qing,Tu Jinpeng,et al.Clinical outcomes of pediatric en bloc kidney transplantation[J].Journal of Clinical Pediatric Surgery,,21():974-979.[doi:10.3760/cma.j.cn101785-202202044-013]
Clinical outcomes of pediatric en bloc kidney transplantation
- Keywords:
- En Bloc Kidney Transplantation (EBKT); Complications; Proteinuria; Pediatric Donor; Single-Kidney Transplantation (SKT)
- Abstract:
- Objective To summarize the clinical outcomes of en bloc kidney transplantation (EBKT) from pediatric donors at a single center and summarize the experiences and lessons.Methods Thirty-six pediatric to adult EBKTs were performed between July 2011 and February 2022.The primary outcome variable was en-bloc allograft survival rate.Secondary outcome variables included incidence of graft failure and incidence of urological complications.The postoperative occurrences of such complications as proteinuria and hemorrhage were recorded along with overall survival and serum creatinine during 3-year follow-ups.Results Both 1/3-year graft survival rates were 83%(30/36) and the recipient survival rate was 100%(36/36).And 30 recipients achieved long-term graft survival.Improvement of creatinine level was noted up until the third year.Graft failure was a serious posttransplant complication with an incidence of 16.7%(6/36).Other complications included urological complications (16.7%,6/36) and hemorrhage (11.1%,4/36).The percentage of patients with proteinuria declined gradually and proteinuria subsided largely during follow-ups.Conclusion EBKT from pediatric donors is associated with excellent long-term allograft and patient survivals.It is a feasible strategy of expanding the transplant donor pool.
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Memo
收稿日期:2022-2-21。
基金项目:天津市卫生健康委员会科技项目(KJ20128、KJ20122、KJ20111、ZC20227、KJ20090)
通讯作者:莫春柏,Email:mochunbaitj@126.com