Teng Teng,Liu Jiangbin,Lv Zhibao.Treatment of vaginal endodermal sinus tumor with chemotherapy and surgery in infants[J].Journal of Clinical Pediatric Surgery,,19():717-720.[doi:10.3969/j.issn.1671-6353.2020.08.011]
Treatment of vaginal endodermal sinus tumor with chemotherapy and surgery in infants
- Keywords:
- Vaginal Neoplasms; Antineoplastic Combined Chemotherapy Protocols; Urogenital Surgical Procedures; Child
- CLC:
- R730.53;R730.56;R737.34
- Abstract:
- Objective To summarize the clinical data of vaginal endodermal sinus tumor in infants and explore the efficacies of transabdominal or transvaginal resection of local foci plus chemotherapy for vaginal endodermal sinus tumor. Methods From November 2012 to May 2016, clinical data were retrospectively analyzed for 5 infants with vaginal endodermal sinus tumor. The average onset age was (6.8±3.87)(3-14) months. All cases belonged to COG stage Ⅲ. Pathological types were confirmed by biopsy through vagina by cystoscopy and preoperative chemotherapy of BEP/VIP prescribed. Based upon the findings of imaging studies and vaginal cystoscopy, transabdominal or transvaginal resection of foci tumor was performed after chemotherapy. Results The initial symptoms were vaginal bleeding. The serum AFP levels significantly decreased after 2-5 courses of chemotherapy[pre-chemotherapy 6455.8 (713.55-18647) ng/mL, pre-operation 17.74(4.09-36.4) ng/mL]. The size of tumor significantly declined[pre-chemotherapy 3.2(1.74-4.33) cm, pre-operation 1.28(0.8-2.0) cm]. Marginal tumor cells persisted (n=2). All received 2-4 courses of chemotherapy. The average follow-up period was (29.8±14.85)(17-55) months. The serum levels of AFP were normal and imaging examination revealed no recurrence. All cases survived tumor-free. Conclusion For vaginal endodermal sinus tumors, chemotherapy plus transvaginal or transabdominal focal surgery may obtain excellent outcomes and preserve fertility function in infants.
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Memo
收稿日期:2018-04-13。
通讯作者:刘江斌,Email:ljbin888@163.com