Sun Jinsong,Liu Dandan,Zhang Gang,et al.Clinicopathological study of congenital ureteropelvic junction obstruction.[J].Journal of Clinical Pediatric Surgery,,17():429-432.
Clinicopathological study of congenital ureteropelvic junction obstruction.
Journal of Clinical Pediatric Surgery[ISSN:1671-6353/CN:43-1380/R]
volume:
第17卷
Number:
2018 06
Page:
429-432
Column:
专题讨论
Date of publication:
2018-06-28
- Document code:
- A
- Abstract:
- ObjectiveTo explore the pathogenesis of congenital ureteropelvic junction obstruction (UPJO) in the etiology of congenital hydronephrosis. MethodsThirty specimens of UJPO (without lumen oppression or neoplasm) were collected. And 11 homochronous specimens of UPJ (from cases of renal tumors without an infiltration of tumor cells in UPJ) were selected as controls. The histological changes and distribution density of markers of nerve fibers and ICC were surveyed.ResultsIn case group, there were fibrous hyperplasia, muscular hypertrophy and collagen hyperplasia. Microfilaments proteins were negative in most lesion segments and only few samples showed weak positive expression with abnormal morphology. Few ICCs expressed Ckit in muscular lesion segment of UPJ. Compared with control group, the difference was significant in distribution density of markers (P<0.01). ConclusionA reduction of nerve fibers and ICC may play an important role in the etiology of UPJO. Clinically, ureteropelvic junction stenosis should be totally removed for preventing recurrence.
Last Update:
2018-06-26