Bai Lishuang,Yang Bo,Tang Yunman,et al.Analysis of prognostic factors in children with monosymptomatic nocturnal enuresis[J].Journal of Clinical Pediatric Surgery,,():611-615.[doi:10.3760/cma.j.cn101785-20260403-00154]
Analysis of prognostic factors in children with monosymptomatic nocturnal enuresis
- Keywords:
- Enuresis; Influencing Factor; Prognostic Analysis
- Abstract:
- Objective To analyze the prognostic factors associated with monosymptomatic nocturnal enuresis (MNE) in children. Methods This study retrospectively analyzed the data of 529 children with MNE admitted to the pediatric surgery outpatient department of Sichuan Provincial People’s Hospital from July 2024 to December 2025.According to treatment efficacies,they were assigned into two groups of cured (n=423) and uncured (n=106).Basic profiles,frequency of enuresis,therapeutic duration and comorbidities[a family history of enuresis,adenoid/tonsillar hypertrophy,spina bifida occulta and attention deficit hyperactivity disorder (ADHD) & constipation were collected.Multivariate Logistic regression analysis was employed for screening the prognostic factors.Results Univariate analysis revealed that age,frequency of enuresis,therapeutic duration,a family history of enuresis,adenoid/tonsillar hypertrophy,spina bifida occulta,ADHD and constipation (all P<0.05) were risk factors for poor prognosis of MNE.Multivariate Logistic regression analysis indicated that constipation (OR=0.04,95%CI:0.01-0.13),enuresis 4-7 times per week (OR=0.11,95%CI:0.05-0.24),adenoid/tonsillar hypertrophy (OR=0.10,95%CI:0.02-0.53),ADHD (OR=0.11,95%CI:0.02-0.76),spina bifida occulta (OR=0.20,95%CI:0.05-0.80) and a family history of enuresis (OR=0.26,95%CI:0.07-0.96) were independent risk factors for poor prognosis of MNE (all P<0.05).Therapeutic duration >6 month (OR=43.79,95%CI:5.85-327.60) was an independent protective factor (P<0.001).And area under the curve (AUC) of the model for predicting prognosis was 0.899 (P<0.001).Conclusion Constipation,frequent enuresis,adenoid/tonsillar hypertrophy,ADHD,spina bifida occulta and a family history of enuresis are independent risk factors for poor prognosis of MNE.And therapeutic duration >6 month may significantly boost cure rate.
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Memo
收稿日期:2026-4-3。
基金项目:国家自然科学基金(82101666)
通讯作者:王学军,Email:wangxuejun028@sina.com