Zhang Yunqiang,Wu Shuihua,Shen Chenfu,et al.Clinical analysis of transarterial embolization of cerebral arteriovenous malformations in children with oil plus Onyx glue[J].Journal of Clinical Pediatric Surgery,,():1163-1168.[doi:10.3760/cma.j.cn101785-202504046-013]
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Clinical analysis of transarterial embolization of cerebral arteriovenous malformations in children with oil plus Onyx glue

Journal of Clinical Pediatric Surgery[ISSN:1671-6353/CN:43-1380/R] volume: Number: 2025 12 Page: 1163-1168 Column: 论著 Date of publication: 2025-12-28
Author(s):
Zhang Yunqiang1;  Wu Shuihua2;  Shen Chenfu3;  Teng Jingjing1;  Chen Dong1;  Li Wei1;  Tu Lijun4
1. Department of Pediatric Neurosurgery, First Municipal People’s Hospital, Chenzhou 423000, China;
2. Department of Neurosurgery, Affiliated Children’s Hospital, Xiangya Medical College, Central South University (Hunan Provincial Children’s Hospital), Changsha 410007, China;
3. Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha 410002, China;
4. Functional Examination Center, First Municipal People’s Hospital, Chenzhou 423000, China
Keywords:
Cerebral Arteriovenous Malformation; Embolization;  Therapeutic; Transcatheter Arterial Embolization; Coil Onyx Glue; Child
DOI:
10.3760/cma.j.cn101785-202504046-013
Abstract:
Objective To explore the clinical effect and safety of transarterial embolization of cerebral arteriovenous malformation (cAVM) in children with coil and onyx glue. Methods From January 2020 to August 2024,the relevant clinical data were retrospectively reviewed for 30 children with cerebral arteriovenous malformations treated by coil embolization plus Onyx glue at First Municipal People’s Hospital.The angiographic results of cerebral vascular malformations and the related complications were collected before operation and at the last follow-up after operation.The outcomes were evaluated by modified Rankin Scale (MRS) at Month 6 after operation. Results Spetzler-Martin grade Ⅰ~Ⅱ (n=21),grade Ⅲ (n=3) and grade Ⅳ~Ⅴ (n=6) children were successfully managed with coil embolization plus Onyx glue with a success rate of 100%.Among them,21 cases (21/30,70%) of grade Ⅰ~Ⅱ were completely closed after one embolization; Nine patients (9/30,30%) with grade Ⅲ~Ⅴ underwent secondary embolization.At Month 3,imaging reexamination indicated that 24 cases (24/30,80%) had no development of malformation mass and 6 cases (6/30,20%) with a small amount of residual malformation mass in original lesion area required further treatment.The success rate of complete embolization was 80%.Postoperative complications of hemorrhage (n=2) and cerebral vasospasm (n=1) were relieved after conservative measures.The follow-up period was (6-12) month after discharge.The modified Mrs score was 0 (n=15),1 (n=13),2 (n=1) and 3 (n=1).According to the literature,complete embolization rate with Onyx glue alone was 74%,complication rate 15% and recurrence rate 12.5%; The complete embolization rate of coil was 67.5%,complication rate 12.5% and recurrence rate 14%.The success rate of coil plus Onyx glue embolization was significantly higher and postoperative complications (10% vs.15%; 10% vs.12.5%) and recurrence rate (6.7% vs.17.5%; 6.7% vs.14%) were significantly lower. Conclusions Using coil plus Onyx glue embolization for cerebral arteriovenous malformations in children has high complete embolization rate,controllable complications and decent prognoses.

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Memo

收稿日期:2025-10-8。
基金项目:郴州市科学技术局科技发展计划项目(ZDYF2020078)
通讯作者:涂丽君,Email:511439643@qq.com

Last Update: 2025-12-28