Li Juan,Nan Guoxin.Research advances on inflammatory factors and signaling pathways in the mechanism of scar formation[J].Journal of Clinical Pediatric Surgery,,():687-691.[doi:10.3760/cma.j.cn101785-202404043-016]
Research advances on inflammatory factors and signaling pathways in the mechanism of scar formation
- Keywords:
- Scar; Inflammatory Factors; Signaling Pathway
- Abstract:
- Scar formation is an abnormal product caused by excessive proliferation of fibrous cells and excessive collagen deposition during the repair and healing process of human muscle surface after trauma.It may affect the appearance or cause teratogenesis and disability so that surgical intervention is often required.Current treatments for scars include surgery,laser treatment,photodynamics and drug intervention,etc.However,clinical efficacy remained non-satisfactory and recurrence rate stays high.It brings great troubles to patients.This review summarized the current research status of scar formation mechanism and discussed the latest researches on interleukin 6 (IL-6),transforming growth factor-β (TGF-β) and tumor necrosis factor-α (TNF-α),fibroblast-related signaling pathways,angiogenesis-related signaling pathways and epithelial-mesenchymal transition (EMT),etc.The goal was to provide the rationales of medication for early prevention of scar formation and develop new therapeutic targets for scar.
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Memo
收稿日期:2024-4-17。
基金项目:东莞市社会发展科技重点项目(20231800939922);广东省基础与应用基础研究项目-区域联合基金-地区培育项目(2021B1515140002)
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