Wu Ying,Ren Hongxi,Wu Xiaoxia,et al.Outcomes of integrated prenatal diagnosis and postpartum treatment of meconium peritonitis[J].Journal of Clinical Pediatric Surgery,2025,(04):351-355.[doi:10.3760/cma.j.cn101785-202409065-009]
Outcomes of integrated prenatal diagnosis and postpartum treatment of meconium peritonitis
- Keywords:
- Meconium Peritonitis; Peripartum Period; Disease Management; Pathological Conditions; Signs and Symptoms; Treatment Outcome; Root Cause Analysis
- Abstract:
- Objective To explore the clinical outcomes and significance of integrated prenatal diagnosis and postpartum treatment of meconium peritonitis (MP).Methods A retrospective analysis was conducted for the relevant clinical data of 81 neonates born with MP operated at Department of Neonatal Surgery,Children’s Hospital of Shanxi Province,from October 2011 to July 2024.According to whether the neonates received integrated prenatal diagnosis and postpartum treatment,they were assigned into two groups of integrated prenatal diagnosis and postpartum treatment (n=27) and non-integrated prenatal diagnosis and postpartum treatment (n=54).The inter-group differences in general perioperative profiles,length of hospitalization stay,pathological type,surgical approach and presence of postoperative complications were compared.Based upon clinical outcomes,they were also divided into two groups of abandonment/death (n=21) and survival (n=60).Integrated prenatal diagnosis and postpartum treatment was employed as an important influencing factor for comparing the inter-group differences in general profiles,pathological types and surgical approaches.Furthermore the prognostic impact of integrated prenatal diagnosis and postpartum treatment was examined through multifactorial Logistic regression analysis.Results Preoperative level of C-reactive protein (CRP) and case number of abandonment/death were lower in integrated prenatal diagnosis and postpartum treatment group than those in non-integrated prenatal diagnosis and postpartum treatment group .There were statistically significant differences (P<0.001,P=0.007).In clinical outcome groups,statistically significant differences existed in whether or not adopting integrated prenatal diagnosis and postpartum treatment,pathological typing and postoperative complications of short bowel syndrome (SBS) (P=0.007,P=0.022,P=0.018).Integrated prenatal diagnosis and postpartum treatment (OR=5.951,95%CI:1.175~30.144,P=0.031) was a protective factor for the prognosis of MP patients.And the presence of SBS was a risk factor for the prognosis of MP children (OR=0.199,95%CI:0.053~0.744,P=0.016).Conclusions Integrated prenatal diagnosis and postpartum treatment may effectively control the progression of MP,lower the rate of abandonment/mortality and have a positive significance for prognosis.
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Memo
收稿日期:2024-3-25。
基金项目:山西省儿童医院院内课题(2023002)
通讯作者:任红霞,Email:renhongxia100@sina.com