Sun Yan,Wang Bing,Gao Sinan,et al.Correlation between changes of intestinal mucosal barrier function and carbapenem-resistant enterobacter colonization during perioperative period of pediatric liver transplantation[J].Journal of Clinical Pediatric Surgery,2025,(03):215-219.[doi:10.3760/cma.j.cn101785-202412011-003]
Correlation between changes of intestinal mucosal barrier function and carbapenem-resistant enterobacter colonization during perioperative period of pediatric liver transplantation
- Keywords:
- Liver Transplantation; Carbapenem-resistant Enterobacteria; D-lactic Acid; Diamine Oxidase; Surgical Procedures; Operative; Child
- Abstract:
- Objective To explore the correlation between intestinal mucosal barrier function impairment and rectal colonization of carbapenem-resistant enterobacteria (CRE) during pediatric liver transplantation (LT) and summarize the general rules of postoperative intestinal mucosal impairment and repairing.Methods From November 1st,2022 to December 31st,2022,40 children with biliary atresia (BA) undergoing LT were assigned into two groups of CRE colonization and non-CRE colonization according to the results of anal swabs.At 24 h pre-operation,24 h post-operation and Day 7 post-operation,venous blood samples were collected for detecting the levels of D-lactic acid and diamine oxidase (DAO).The inter-group differences and changes of D-lactic acid and DAO were compared.And general rules of intestinal mucosal impairment and repairing post-LT was preliminarily examined.Results The levels of D-lactic acid and DAO peaked at 24 h post-operation in both groups.In CRE colonization group,D-lactic acid of 24 h post-operation and 24 h pre-operation,24 h post-operation and Day 7 post-operation .In non-CRE colonization group,D-lactic acid of 24 h post-operation and 24 h pre-operation,24 h post-operation and Day 7 post-operation ; D-lactic acid of 24 h post-operation in CRE colonization and non-CRE colonization groups.The differences were statistically significant (P<0.05); In CRE colonization group,DAO of 24 h post-operation and 24 h pre-operation [(0.22±0.04) vs.(0.16±0.05) U/L],24 h post-operation and Day 7 post-operation .In non-CRE colonization group,DAO of 24 h post-operation and 24 h pre-operation [(0.17±0.01) vs. (0.13±0.02)U/L],24 h post-operation and Day 7 post-operation,DAO of 24 h post-operation in CRE colonization and non-CRE colonization groups .The differences were statistically significant (P<0.05).However,the levels of D-lactic acid and DAO at 24 h pre-operation and Day 7 post-operation had no significant differences in neither groups.The levels of D-lactic acid and DAO at 24 h pre-operation and Day 7 post-operation had no significant inter-group differences.Conclusions Intestinal mucosal injury peaked within 24 h post-LT and returned to the preoperative level within 1 week.In CRE colonization group,intestinal mucosal barrier injury was more severe than that in non-CRE colonization group.
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Memo
收稿日期:2024-12-3。
基金项目:国家自然基金项目(32371426);天津市自然科学基金(21JCYBJC01290);天津市卫生健康科技重点学科专项(TJWJ2023XK012);感染性疾病国家临床重点专科建设项目(8235)
通讯作者:王兵,Email:sy.sindy@163.com