Shen Yiding,Zhao Dongyan,Yang Xiuzhen.Advances in the application of ultrasonic diagnosis in adolescent varicocele[J].Journal of Clinical Pediatric Surgery,,():97-100.[doi:10.3760/cma.j.cn101785-202208018-018]
Advances in the application of ultrasonic diagnosis in adolescent varicocele
- Keywords:
- Ultrasonography; Doppler; Varicocele; Surgical Procedures; Operative; Child
- Abstract:
- Varicocele typically develops during adolescence and can affect sexual development and reproductive health in male adolescents,potentially leading to fertility issues in adulthood.In adult,pregnancy rates and semen parameters are direct indicators of the consequences of varicocele; however,similar evaluation metrics are challenging to obtain in adolescents.Ultrasound imaging,as a non-invasive and cost-effective technique,provides a range of parameters (such as peak reflux velocity in the spermatic veins,testicular atrophy index,and testicular tissue stiffness) that play a significant role in the diagnosis,classification,disease progression prediction,and prognostic evaluation of adolescent varicocele.This review summarizes the clinical applications of ultrasound diagnostic techniques in adolescent varicocele.
References:
[1] Su JS, Farber NJ, Vij SC.Pathophysiology and treatment options of varicocele:an overview[J]. Andrologia, 2021, 53(1):e13576.DOI:10.1111/and.13576.
[2] Silay MS, Hoen L, Quadackaers J, et al.Treatment of varicocele in children and adolescents:a systematic review and meta-analysis from the European Association of Urology/European Society for Paediatric Urology Guidelines Panel[J]. Euro Urol, 2019, 75(3):448-461.DOI:10.1016/j.eururo.2018.09.042.
[3] Freeman S, Bertolotto M, Richenberg J, et al.Ultrasound evaluation of varicoceles:guidelines and recommendations of the European Society of Urogenital Radiology Scrotal and Penile Imaging Working Group (ESUR-SPIWG) for detection, classification, and grading[J]. Eur Radiol, 2020, 30(1):11-25.DOI:10.1007/s00330-019-06280-y.
[4] Kitami M.Ultrasonography of pediatric urogenital emergencies:review of classic and new techniques[J]. Ultrasonography, 2017, 36(3):222-238.DOI:10.14366/usg.17011.
[5] Foroughi AA, Yazdanpanah E, Nazeri M, et al.Clinical grading and color Doppler ultrasonography-based grading of varicocele:how compatible are the two grading systems?[J]. World J Urol, 2019, 37(7):1461-1465.DOI:10.1007/s00345-018-2528-8.
[6] Hoekstra T, Witt MA.The correlation of internal spermatic vein palpability with ultrasonographic diameter and reversal of venous flow[J]. J Urol, 1995, 153(1):82-84.DOI:10.1097/00005392-199501000-00029.
[7] Paduch DA, Niedzielski J.Semen analysis in young men with varicocele:preliminary study[J]. J Urol, 1996, 156(2 Pt 2):788-790.DOI:10.1097/00005392-199608001-00063.
[8] Welliver C, Cardona-Grau D, Elebyjian L, et al.Surprising interobserver and intra-observer variability in pediatric testicular ultrasound volumes[J]. J Pediatr Urol, 2019, 15(4):386.e1-386.e6.DOI:10.1016/j.jpurol.2019.04.016.
[9] Verim S, Uguz S, Celikkanat S, et al.Prognostic predictors of fertility in young adult patients with varicocele:peak retrograde flow velocity and reflux grade[J]. J Ultrasound Med, 2016, 35(6):1241-1250.DOI:10.7863/ultra.15.07072.
[10] De Win G, De Neubourg D, De Wachter S, et al.Peak retrograde flow a potential objective management tool to identify young adults with varicocele ’at risk’ for a high sperm DNA fragmentation[J]. J Pediatr Urol, 2021, 17(6):760.e1-760.e9.DOI:10.1016/j.jpurol.2021.09.018.
[11] Cannarella R, Calogero AE, Condorelli RA, et al.Management and treatment of varicocele in children and adolescents:an endocrinologic perspective[J]. J Clin Med, 2019, 8(9):1410.DOI:10.3390/jcm8091410.
[12] 郑杰文, 唐耘熳.青少年精索静脉曲张的手术指征探讨[J]. 临床小儿外科杂志, 2019, 18(4):341-344.DOI:10.3969/j.issn.1671-6353.2019.04.019. Zheng JW, Tang YM.Surgical indications for varicocele in youth and adolescence[J]. DOI:10.3969/j.issn.1671-6353.2019.04.019.
[13] Kurtz MP, Zurakowski D, Rosoklija I, et al.Semen parameters in adolescents with varicocele:association with testis volume differential and total testis volume[J]. J Urol, 2015, 193(5 Suppl):1843-1847.DOI:10.1016/j.juro.2014.10.111.
[14] Locke JA, Noparast M, Afshar K.Treatment of varicocele in children and adolescents:a systematic review and meta-analysis of randomized controlled trials[J]. J Pediatr Urol, 2017, 13(5):437-445.DOI:10.1016/j.jpurol.2017.07.008.
[15] Van Batavia JP, Lawton E, Frazier JR, et al.Total motile sperm count in adolescent boys with varicocele is associated with hormone levels and total testicular volume[J]. J Urol, 2021, 205(3):888-894.DOI:10.1097/ju.0000000000001405.
[16] Kurtz MP, Rosoklija I, Kringle G, et al.Prepubertal presentation of varicocele does not affect outcomes[J]. J Pediatr Urol, 2015, 11(2):73.e1-73.e4.DOI:10.1016/j.jpurol.2014.09.012.
[17] Khasnavis S, Kogan BA.Natural history of testicular size in boys with varicoceles[J]. J Pediatr Urol, 2015, 11(3):148.e1-148.e5.DOI:10.1016/j.jpurol.2015.02.014.
[18] Vaganée D, Daems F, Aerts W, et al.Testicular asymmetry in healthy adolescent boys[J]. BJU Int, 2018, 122(4):654-666.DOI:10.1111/bju.14174.
[19] Sorokin I, Welliver C, Elebyjian L, et al.Interinstitutional variability in testicular volumes and varicocele presence by ultrasound:surprising discrepancies and implications for clinical decision making[J]. Urology, 2015, 85(5):1079-1084.DOI:10.1016/j.urology.2015.02.018.
[20] Bello JO, Bhatti KH, Gherabi N, et al.The usefulness of elastography in the evaluation and management of adult men with varicocele:a systematic review[J]. Arab J Urol, 2021, 19(3):255-263.DOI:10.1080/2090598X.2021.1964256.
[21] Rocher L, Criton A, Gennisson JL, et al.Testicular shear wave elastography in normal and infertile men:a prospective study on 601 patients[J]. Ultrasound Med Biol, 2017, 43(4):782-789.DOI:10.1016/j.ultrasmedbio.2016.11.016.
[22] Turna O, Aybar MD.Testicular stiffness in varicocele:evaluation with shear wave elastography[J]. Ultrasonography, 2020, 39(4):350-355.DOI:10.14366/usg.19087.
[23] Mulati Y, Li XD, Maimaitiming A, et al.Is there any predictive value of testicular shear wave elastic modulus in testicular functions for varicocele patients?[J]. Andrologia, 2022, 54(5):e14393.DOI:10.1111/and.14393.
[24] Erdo?an H, Durmaz MS, ?zbak?r B, et al.Experience of using shear wave elastography in evaluation of testicular stiffness in cases of male infertility[J]. J Ultrasound, 2020, 23(4):529-534.DOI:10.1007/s40477-020-00430-5.
[25] Fuschi A, Capone L, Abuorouq S, et al.Shear wave elastography in varicocele patients:prospective study to investigate correlation with semen parameters and histological findings[J]. Int J Clin Pract, 2021, 75(3):e13699.DOI:10.1111/ijcp.13699.
[26] Abdelwahab K, Eliwa AM, Seleem MM, et al.Role of preoperative testicular shear wave elastography in predicting improvement of semen parameters after varicocelectomy for male patients with primary infertility[J]. Urology, 2017, 107:103-106.DOI:10.1016/j.urology.2017.04.026.
[27] Ryu YJ, Choi YH, Kim JY, et al.A preliminary study of shear-wave elastography for the evaluation of varicocele in adolescents and young adults[J]. Ultrasonography, 2022, 41(1):131-139.DOI:10.14366/usg.20213.
[28] Shin HJ, Yoon H, Lee YS, et al.Normal changes and ranges of pediatric testicular volume and shear wave elasticity[J]. Ultrasound Med Biol, 2019, 45(7):1638-1643.DOI:10.1016/j.ultrasmedbio.2019.02.026.
[29] Durmaz MS, Sivri M, Sekmenli T, et al.Experience of using shear wave elastography imaging in evaluation of undescended testes in children:feasibility, reproducibility, and clinical potential[J]. Ultrasound Q, 2018, 34(4):206-212.DOI:10.1097/RUQ.0000000000000344.
[30] Shin HJ, Lee YS, Yoon H, et al.Testicular volume and elasticity changes in young children with undescended testes[J]. Med Ultrason, 2017, 19(4):380-385.DOI:10.11152/mu-1093.
[31] Kü?ükdurmaz F, Sar?ca MA, Emre ?, et al.Evaluation of the diagnostic efficacy of strain elastography in infertile population with normal and abnormal semen parameters[J]. Turk J Urol, 2017, 43(3):261-267.DOI:10.5152/tud.2017.34793.
[32] Salama N, Samir M, Blgozah S.Evaluation of normal and varicocele-bearing testes using real-time strain elastography[J]. J Ultrasound Med, 2019, 38(3):621-627.DOI:10.1002/jum.14730.
[33] Bitkin A, Ba?ak Ozbalci A, Aydin M, et al.Effects of varicocele on testicles:value of strain elastography:a prospective controlled study[J]. Andrologia, 2019, 51(1):e13161.DOI:10.1111/and.13161.
[34] Mur?ic’ M, Sjekavica I, ?imunovic’ M, et al.The role of ultrasound elastography in the diagnosis of pathologic conditions of testicles and scrotum[J]. Acta Clin Croat, 2021, 60(1):41-49.DOI:10.20471/acc.2021.60.01.06.
[35] Camoglio FS, Bruno C, Peretti M, et al.The role of sonoelastography in the evaluation of testes with varicocele[J]. Urology, 2017, 100:203-206.DOI:10.1016/j.urology.2016.08.005.
[36] Yan S, Shabbir M, Yap T, et al.Should the current guidelines for the treatment of varicoceles in infertile men be re-evaluated?[J]. Hum Fertil (Camb), 2021, 24(2):78-92.DOI:10.1080/14647273.2019.1582807.
Memo
收稿日期:2022-8-9。
基金项目:浙江省科技厅公益研究计划(LGF22H040006)
通讯作者:杨秀珍,Email:9712004yxz@zju.edu.cn