Wu Hao,Han Yijiang,Gao Zhigang,et al.Role of bile acids in the progression of biliary atresia and related research advances[J].Journal of Clinical Pediatric Surgery,,():745-749.[doi:10.3760/cma.j.cn101785-202208047-008]
Role of bile acids in the progression of biliary atresia and related research advances
- Keywords:
- Biliary Atresia; Bile Acid; Prognosis
- Abstract:
- Biliary atresia,as the main component of bile,have physiological functions such as digesting lipids,regulating gut microbiota,and controlling metabolism.Children with biliary atresia often experience varying degrees of bile acid metabolism disorders.Bile acids are amphiphilic molecules,with hydrophobic bile acids generally exhibiting higher cytotoxicity.In the pathological state of biliary atresia,the inherent cytotoxicity of bile acid is amplified,contributing to a series of pathological changes.Conversely,hydrophilic bile acids,such as ursodeoxycholic acid,can significantly improve liver function,a characteristic currently used in the treatment of biliary atresia.Serum bile acid levels increase with the severity of liver fibrosis,which can be useful for assessing the extent of liver damage.This article reviews the relationship between the toxic effects of bile acids and the pathophysiological changes in biliary atresia,and briefly introduces current diagnostic and therapeutic approaches related to bile acids in the management of biliary atresia,providing references for clinical and research work.
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Memo
收稿日期:2022-8-25。
基金项目:国家中心自主设计项目(S20C0004)
通讯作者:钭金法,Email:toujinfa@zju.edu.cn