Yang Wei,Liu Shan,Ren Qinghua,et al.Hepatectomy for multifocal hepatoblastoma:a single-center report[J].Journal of Clinical Pediatric Surgery,,():543-549.[doi:10.3760/cma.j.cn101785-202310006-007]
Hepatectomy for multifocal hepatoblastoma:a single-center report
- Keywords:
- Hepatoblastoma; Surgical Procedures; Operative; Treatment Outcome; Clinical Study; Child
- Abstract:
- Objective To explore the feasibility and effectiveness of hepatectomy for multifocal hepatoblastoma (HB).Methods A retrospective analysis was conducted for 21 hospital cases of multifocal HB patients from April 2014 to December 2022.Clinical characteristics,surgical procedures and long-term outcomes were collected and compared with 58 cases of unifocal hepatoblastoma patients with intermediate/high-risk group during the same period.Results Among 21 children with multifocal HB,there were 2 tumor foci (n=11),3 tumor foci (n=4) and 5 tumor foci (n=1).Five cases had more than five intrahepatic tumor foci and a definite count was impossible.Tumor resection was anatomical (n=9),irregular (n=11) and combined liver dissection and portal vein ligation for staged hepatectomy (ALPPS,n=1).R0 resection (n=20) and R1 resection (n=1) were performed without serious postoperative complications.After receiving multidisciplinary comprehensive treatment of surgery plus chemotherapy,median follow-up time for multifocal HB was 57 months.The outcomes were disease-free survival (n=18) and death (n=3).The 3-year event free survival (EFS),3-year overall survival (OS) and cumulative incidence of local progression (CILP) in children with multifocal HB were 57.58%,82.00% and 38.00% respectively.The above parameters of single focus intermittent/high-risk HB admitted during the same period were 91.84%,74.96% and 20.04% respectively.No significant statistical difference existed between two datasets.Conclusions For multifocal HB,standardized surgical resection plus perioperative chemotherapy may achieve satisfactory outcomes.It provides an effective treatment for multifocal HB children.
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Memo
收稿日期:2023-10-07。
基金项目:国家自然科学基金(82293660/82293665)
通信作者:王焕民,Email:wanghuanmin@bch.com.cn