Zhang Bo,Hou Yaru,Kang Xuelian,et al.Research advances in etiology of congenital anorectal malformations[J].Journal of Clinical Pediatric Surgery,,():496-500.[doi:10.3760/cma.j.cn101785-202302029-020]
Research advances in etiology of congenital anorectal malformations
- Keywords:
- Anorectal Malformations; Surgical Procedures; Operative; Child
- Abstract:
- Anorectal malformation (ARM) is the most common congenital gastrointestinal malformation in children.It has a low prenatal diagnostic rate.The major treatments include posterior sagittal anoplasty and laparoscopic-assisted anoplasty.Most children develop postoperative complications.Understanding its etiology is helpful to prevent its occurrence and develop more appropriate treatments.Domestic and foreign scholars believe that the occurrence of ARM may be related to chromosomal abnormalities,syndrome associated factors,environmental factors and some unfavorable prenatal habits and maternal factors.Since its specific etiology has remained elusive,this review was intended to elucidate the pathogenesis of ARM from genetic and non-genetic factors and focused upon the pathogenesis of ARM and related signaling pathways and genes.
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Memo
收稿日期:2023-02-20。
基金项目:甘肃省哲学社会科学规划项目(SH036)
通讯作者:李勇, Email:3144196718@qq.com