Wang Peixin,Zhao Jun,Wang Xingsheng,et al.Research advances of correlation between estrogen and idiopathic scoliosis[J].Journal of Clinical Pediatric Surgery,,():493-495.[doi:10.3760/cma.j.cn101785-202208053-019]
Research advances of correlation between estrogen and idiopathic scoliosis
- Keywords:
- Estrogens; Spinal Diseases; Surgical Procedures; Operative; Child
- Abstract:
- As one of common spinal diseases in children and adolescents,idiopathic scoliosis (IS) has so many complex influencing factors as to seriously affect the quality of life and physical and mental health.Estrogen may directly or indirectly modulate the occurrence and development of IS through abnormal regulations of bone metabolism and its effect on paravertebral muscles via receptors.Elucidating the underlying mechanism offers a novel therapeutic strategy.This review summarized the latest researches on correlation between estrogen and IS.
References:
[1] 毛晓艳,刘云,梁舒涵,等.三步五法正脊术对于青少年特发性脊柱侧凸患者Cobb角的影响[J].中医药导报,2016,22(8):64-66.DOI:10.13862/j.cnki.cn43-1446/r.2016.08.021. Mao XY,Liu Y,Liang SH,et al.Effects of three-step five-method spinesetting on the Cobb angle of adolescent idiopathic scoliosis[J].Guid J Tradit Chin Med Pharm,2016,22(8):64-66.DOI:10.13862/j.cnki.cn43-1446/r.2016.08.021.
[2] Liang ZT,Guo CF,Li J,et al.The role of endocrine hormones in the pathogenesis of adolescent idiopathic scoliosis[J].FASEB J,2021,35(9):e21839.DOI:10.1096/fj.202100759R.
[3] Mao SH,Jiang J,Sun X,et al.Timing of menarche in Chinese girls with and without adolescent idiopathic scoliosis:current results and review of the literature[J].Eur Spine J,2011,20(2):260-265.DOI:10.1007/s00586-010-1649-6.
[4] Fan JZ,Yang L,Meng GL,et al.Estrogen improves the proliferation and differentiation of hBMSCs derived from postmenopausal osteoporosis through notch signaling pathway[J].Mol Cell Biochem,2014,392(1/2):85-93.DOI:10.1007/s11010-014-2021-7.
[5] Tian LJ,Guo YS,Guo ZM.Association between serum β-oestradiol and health-related quality of life in postmenopausal women with degenerative lumbar scoliosis[J].Clin Endocrinol (Oxf),2023,98(1):91-97.DOI:10.1111/cen.14786.
[6] Ma YG,Chai Z,Ren LL,et al.Bazedoxifene effects on osteoprotegerin,insulin-like growth factor,tumor necrosis factor and bone mineral density[J].Cell Mol Biol (Noisy-le-grand),2020,66(3):109-112.
[7] Bahamonde M,Misra M.Potential applications for rhIGF-I:bone disease and IGFI[J].Growth Horm IGF Res,2020,52:101317.DOI:10.1016/j.ghir.2020.101317.
[8] Liedert A,Nemitz C,Haffner-Luntzer M,et al.Effects of estrogen receptor and Wnt signaling activation on mechanically induced bone formation in a mouse model of postmenopausal bone loss[J].Int J Mol Sci,2020,21(21):8301.DOI:10.3390/ijms21218301.
[9] Cheng CH,Chen LR,Chen KH.Osteoporosis due to hormone imbalance:an overview of the effects of estrogen deficiency and glucocorticoid overuse on bone turnover[J].Int J Mol Sci,2022,23(3):1376.DOI:10.3390/ijms23031376.
[10] McNamara LM.Osteocytes and estrogen deficiency[J].Curr Osteoporos Rep,2021,19(6):592-603.DOI:10.1007/s11914-021-00702-x.
[11] Yoshida T,Wang J,Stern PH.Gonadal hormones and bone[J].Handb Exp Pharmacol,2020,262:65-91.DOI:10.1007/164_2019_327.
[12] Kudo D,Miyakoshi N,Hongo M,et al.Nerve growth factor and estrogen receptor mRNA expression in paravertebral muscles of patients with adolescent idiopathic scoliosis:a preliminary study[J].Spine Deform,2015,3(2):122-127.DOI:10.1016/j.jspd.2014.07.006.
[13] Janusz P,Chmielewska M,Andrusiewicz M,et al.Methylation of estrogen receptor 1 gene in the paraspinal muscles of girls with idiopathic scoliosis and its association with disease severity[J].Genes (Basel),2021,12(6):790.DOI:10.3390/genes12060790.
[14] Janusz P,Chmielewska M,Andrusiewicz M,et al.Methylation level of the regulatory regions of the estrogen receptor type 1 gene in paravertebral muscles of girls with idiopathic scoliosis[J].Stud Health Technol Inform,2021,280:254.DOI:10.3233/SHTI210484.
[15] Chmielewska M,Janusz P,Andrusiewicz M,et al.Methylation of estrogen receptor 2(ESR2) in deep paravertebral muscles and its association with idiopathic scoliosis[J].Sci Rep,2020,10(1):22331.DOI:10.1038/s41598-020-78454-4.
Memo
收稿日期:2022-08-28。
基金项目:省级重点人才项目(甘组通字【2022】77号); 联合科研基金重大项目(23JRRA1529); 临床医学研究中心建设项目(21JR7RA681)
通讯作者:赵军,Email:673078008@qq.com