Cai Miao,Li Qi,Wu Shengde,et al.Analysis of risk factors for bladder dysfunction in children with nocturnal enuresis[J].Journal of Clinical Pediatric Surgery,,():234-237.[doi:10.3760/cma.j.cn101785-202112045-006]
Analysis of risk factors for bladder dysfunction in children with nocturnal enuresis
- Keywords:
- Enuresis; Bladder Dysfunction; Power of Urine; Surgical Procedures; Operative; Child
- Abstract:
- Objective To explore the risk factors of bladder dysfunction in children with nocturnal enuresis (NE).Methods From September 2020 to September 2022,343 NE children receiving urinary dynamic pressure-flow rate examination at Urinary Disorders Diagnosis and Treatment Center were selected as study subjects.According to the urodynamic results,they were assigned into two groups of bladder dysfunction (n=157) and non-dysfunction (n=186).Two groups were compared with regards to general profiles (gender,parental education,living environment,bedtime drinking water,history of enuresis,stool,daytime symptoms,weekly frequency of enuresis,bladder volume,urinary flow rate,residual urine & spina bifida),urinary routine,urological system ultrasonography,bococcygeal plain film and free urinary flow rate.Results There were 200 boys and 143 girls with a treatment age of (7.85±2.36) years.Male (OR=2.156,95%CI:1.085-4.285),daytime symptoms(OR=4.471,95%CI:2.229-8.967),lowered functional bladder volume (OR=20.651,95%CI:9.094-46.895),weekly frequency of enuresis ＞4 times (OR=2.339,95%CI:1.131-4.838),reduced urinary flow rate (OR=3.196,95%CI:1.360-7.510) and occult spina bifida (OR=2.359,95%CI:1.160-4.794) were independent risk factors for bladder dysfunction in children.Conclusions Male,daytime symptoms,occulted spina bifida,weekly frequency of enuresis ＞4 times,lowered physiologic bladder volume and decreased urinary flow rate are risk factors for bladder dysfunction in NE children.Routine urodynamic examination is necessary to understand bladder function and provide rationales for standardized management.
References:
[1] 陈咏梅,黄艳,熊琼珍,等.252例儿童夜遗尿症的临床特征分析[J].临床小儿外科杂志,2021,20(6):588-591.DOI:10.12260/lcxewkzz.2021.06.015.Chen YM,Huang Y,Xiong QZ,et al.Retrospective analysis of clinical characteristics of nocturnal enuresis in children:a report of 252 cases[J].J Clin Ped Sur,2021,20(6):588-591.DOI:10.12260/lcxewkzz.2021.06.015.
[2] Miyazato M,Gakiya M,Ashikari A,et al.Evaluation of the influence of a history of childhood nocturnal enuresis on nighttime urinary frequency and the causes of nocturia in adults[J].Urology,2022,164:106-111.DOI:10.1016/j.urology.2022.01.007.
[3] Petros PE,Garcia-Fernandez A.Cure of enuresis/bowel dysfunction in children may provide insights for adult dysfunctions[J].Tech Coloproctol,2021,25(3):351-353.DOI:10.1007/s10151-021-02410-1.
[4] Hussong J,Rosenthal A,Bernhardt A,et al.State and trait anxiety in children with incontinence and their parents[J].Clin Child Psychol Psychiatry,2021,26(4):1243-1256.DOI:10.1177/13591045211033175.
[5] Van Batavia JP,Combs AJ.The role of non-invasive testing in evaluation and diagnosis of pediatric lower urinary tract dysfunction[J].Curr Urol Rep,2018,19(5):34.DOI:10.1007/s11934-018-0784-1.
[6] Yavuz A,Bayar G,Kilinc MF,et al.The relationship between nocturnal enuresis and spina bifida occulta:a prospective controlled trial[J].Urology,2018,120:216-221.DOI:10.1016/j.urology.2018.07.038.
[7] 文建国,牛建华,吴军卫,等.隐性脊柱裂对儿童原发性夜间遗尿症治疗的影响[J].中华小儿外科杂志,2016,37(11):851-855.DOI:10.3760/cma.j.issn.0253-3006.2016.11.011.Wen JG,Niu JH,Wu JW,et al.Impact of spina bifida occulta on the treatments of primary nocturnal enuresis[J].Chin J Pediatr Surg,2016,37(11):851-855.DOI:10.3760/cma.j.issn.0253-3006.2016.11.011.
[8] Peh WYX,Raczkowska MN,Teh Y,et al.Closed-loop stimulation of the pelvic nerve for optimal micturition[J].J Neural Eng,2018,15(6):066009.DOI:10.1088/1741-2552/aadee9.
[9] 文建国,王庆伟,文建军,等.411例遗尿症儿童和青少年的家族史和家系分析[J].中华泌尿外科杂志,2007,28(5):316-318.DOI:10.3760/j:issn:1000-6702.2007.05.008.Wen JG,Wang QW,Wen JJ,et al.Family lineage and segregation studies on children with nocturnal enuresis:a report of 411 cases[J].Chin J Urol,2007,28(5):316-318.DOI:10.3760/j:issn:1000-6702.2007.05.008.
[10] J?rgensen CS,Horsdal HT,Rajagopal VM,et al.Identification of genetic loci associated with nocturnal enuresis:a genome-wide association study[J].Lancet Child Adolesc Health,2021,5(3):201-209.DOI:10.1016/S2352-4642(20)30350-3.
Memo
收稿日期:2021-12-17。
基金项目:国家儿童健康与疾病临床医学研究中心临床医学研究一般项目(NCRCCHD-2020-GP-04)
通讯作者:魏光辉,Email:u806806@cqmu.edu.cn