Xu Xinke,Lin Haoming,Lin Wei,et al.Risk factors of secondary operation for craniosynostosis in children[J].Journal of Clinical Pediatric Surgery,,():125-129.[doi:10.3760/cma.j.cn101785-202312002-005]
Risk factors of secondary operation for craniosynostosis in children
- Keywords:
- Craniosynostoses; Surgical Procedures; Operative; Reoperation; Treatment Outcome; Root Cause Analysis; Child
- Abstract:
- Objective To explore the influencing factors of secondary operation after craniosynostosis in children.Methods From March 2016 to August 2023,the relevant clinical data were retrospectively reviewed for 133 children with craniosynostosis undergoing surgery.They were divided into primary surgery group and secondary surgery group according to whether they received the second surgery or not.Gender,age,type of craniosynostosis,operative approach,operative duration and volume of blood loss were recorded.The possible influencing factors of secondary operation were examined.Results Operation was one-time (n=119) and secondary (n=14).Univariate analysis suggested that the proportion of simple craniosynostomy in the secondary surgery group [7(50.0%)] was significantly higher than that in the single surgery group [14(11.8%)],and the difference was statistically significant (χ2=11.047,P=0.001); the age of the first surgery in the secondary surgery group[7.50(3.75,10.00)months] was lower than that in the single surgery group [11(6,25)months],and the difference was statistically significant (Z=-2.39,P=0.017); the weight of the first surgery in the secondary surgery group [6.75(6.00,8.25)kg] was lower than that in the single surgery group [9(7,11)kg],and the difference was statistically significant (Z=-3.195,P=0.001); the time of the first surgery in the secondary surgery group [120(73.75,185.00)min] was lower than that in the single surgery group [190(135,245)min],and the difference was statistically significant (Z=-2.494,P=0.013); The first intraoperative blood loss in the secondary surgery group [100(50,200)mL] was lower than that in the simple surgery group [200(100,300)mL],and the difference was statistically significant (Z=-2.374,P=0.018).Further multivariate analysis showed that craniosynostomy alone may be a factor influencing the secondary operation (OR=4.406,95%CI:1.038-18.708,P=0.044).Conclusions Craniosynostosis is a common neurological congenital disease in children and surgery is efficacious.Surgical approach is an risk factor for secondary surgery.Simple suturectomy may require secondary operation and it should be properly considered in surgical planning.
References:
[1] Williams JK,Cohen SR,Burstein FD,et al.A longitudinal,statistical study of reoperation rates in craniosynostosis[J].Plast Reconstr Surg,1997,100(2):305-310.DOI:10.1097/00006534-199708000-00003.
[2] Zakhary GM,Montes DM,Woerner JE,et al.Surgical correction of craniosynostosis.A review of 100 cases[J].J Craniomaxillofac Surg,2014,42(8):1684-1691.DOI:10.1016/j.jcms.2014.05.014.
[3] Jubbal KT,Agrawal N,Hollier LHJr.Analysis of morbidity,readmission,and reoperation after craniosynostosis repair in children[J].J Craniofac Surg,2017,28(2):401-405.DOI:10.1097/SCS.0000000000003316.
[4] Utria AF,Lopez J,Cho RS,et al.Timing of cranial vault remodeling in nonsyndromic craniosynostosis:a single-institution 30-year experience[J].J Neurosurg Pediatr,2016,18(5):629-634.DOI:10.3171/2016.5.PEDS1663.
[5] 文海韬,顾硕,吴水华.狭颅症的诊疗进展[J].临床小儿外科杂志,2018,17(2):146-149.DOI:10.3969/j.issn.1671-6353.2018.02.014.Wen HT,Gu S,Wu SH.Research advances of diagnosing and treating craniostenosis[J].J Clin Ped Sur,2018,17(2):146-149.DOI:10.3969/j.issn.1671-6353.2018.02.014.
[6] Massenburg BB,Nassar AH,Hopper RA.National database reported outcomes following craniosynostosis reconstruction[J].J Craniofac Surg,2020,31(1):154-157.DOI:10.1097/SCS.0000000000006067.
[7] Di Rocco F,Gleizal A,Szathmari A,et al.Sagittal suture craniosynostosis or craniosynostoses? The heterogeneity of the most common premature fusion of the cranial sutures[J].Neurochirurgie,2019,65(5):232-238.DOI:10.1016/j.neuchi.2019.09.011.
[8] Dempsey RF,Monson LA,Maricevich RS,et al.Nonsyndromic craniosynostosis[J].Clin Plast Surg,2019,46(2):123-139.DOI:10.1016/j.cps.2018.11.001.
[9] Blessing M,Gallagher ER.Epidemiology,genetics,and pathophysiology of craniosynostosis[J].Oral Maxillofac Surg Clin North Am,2022,34(3):341-352.DOI:10.1016/j.coms.2022.02.001.
[10] Massimi L,Bianchi F,Frassanito P,et al.Imaging in craniosynostosis:when and what?[J].Childs Nerv Syst,2019,35(11):2055-2069.DOI:10.1007/s00381-019-04278-x.
[11] 孟广远,马景孟,邹方田,等.狭颅症手术治疗的远期疗效[J].中华小儿外科杂志,1984,5(3):136-137.DOI:10.3760/cma.j.issn.0253-3006.1984.03.004.Meng GY,Ma JM,Zou FT,et al.Long-term surgical efficacies of craniosynostosis[J].Chin J Pediatr Surg,1984,5(3):136-137.DOI:10.3760/cma.j.issn.0253-3006.1984.03.004.
[12] Frostell A,Haghighi M,Bartek JJr,et al.Improved cephalic index following early cranial vault remodeling in patients with isolated nonsyndromic sagittal synostosis[J].Neurosurg Focus,2021,50(4):E7.DOI:10.3171/2021.1.FOCUS201017.
[13] Kalmar CL,Lang SS,Heuer GG,et al.Neurocognitive outcomes of children with non-syndromic single-suture craniosynostosis[J].Childs Nerv Syst,2022,38(5):893-901.DOI:10.1007/s00381-022-05448-0.
[14] Seruya M,Oh AK,Boyajian MJ,et al.Long-term outcomes of primary craniofacial reconstruction for craniosynostosis:a 12-year experience[J].Plast Reconstr Surg,2011,127(6):2397-2406.DOI:10.1097/PRS.0b013e318213a178.
[15] 魏民,詹琪佳,蒋文彬,等.内镜下颅缝条状切除术治疗矢状缝早闭疗效分析[J].中国现代神经疾病杂志,2023,23(7):621-626.DOI:10.3969/j.issn.1672-6731.2023.07.010.Wei M,Zhan QJ,Jiang WB,et al.Efficacy of endoscopic strip craniectomy for sagittal synostosis[J].Chin J Contemp Neurol Neurosurg,2023,23(7):621-626.DOI:10.3969/j.issn.1672-6731.2023.07.010.
[16] 耿健,董辉,周启荣,等.颅缝再造术与颅盖成形术治疗狭颅症的对比研究[J].中国实用神经疾病杂志,2017,20(2):29-31.DOI:10.3969/j.issn.1673-5110.2017.02.011.Geng J,Dong H,Zhou QR,et al.A comparative study of cranial suture reconstruction and cranioplasty for cranial stenosis[J].Chin J Pract Nerv Dis,2017,20(2):29-31.DOI:10.3969/j.issn.1673-5110.2017.02.011.
[17] 车武强,邓舒,薛皓予,等.双顶部扩大颅缝再造术治疗儿童矢状缝早闭的疗效观察[J].中华神经外科杂志,2022,38(6):566-569.DOI:10.3760/cma.j.cn112050-20220224-00105.Che WQ,Deng S,Xue HY,et al.Observation of therapeutic effect of biparietal cranial suture expansion and cranioplasty for pediatric sagittal synostosis[J].Chin J Neurosurg,2022,38(6):566-569.DOI:10.3760/cma.j.cn112050-20220224-00105..
[18] Mathijssen IMJ,Wolvius EB,Spoor JKH,et al.Secondary vault reconstruction after open or minimal invasive correction for unisutural,multisutural or syndromic craniosynostosis:a cohort study on the impact of diagnosis and type of initial surgical technique[J].J Plast Reconstr Aesthet Surg,2021,74(5):1087-1092.DOI:10.1016/j.bjps.2020.10.049.
[19] Foster KA,Frim DM,McKinnon M.Recurrence of synostosis following surgical repair of craniosynostosis[J].Plast Reconstr Surg,2008,121(3):70e-76e.DOI:10.1097/01.prs.0000299393.36063.de.
[20] Wall SA,Goldin JH,Hockley AD,et al.Fronto-orbital re-operation in craniosynostosis[J].Br J Plast Surg,1994,47(3):180-184.DOI:10.1016/0007-1226(94)90051-5.
Memo
收稿日期:2023-12-1。
基金项目:广州市科技计划项目(2023A03J0897)
通讯作者:李方成,Email:sjwklfc@126.com