Zhou Enqing,Dong Rui.Research advances of berberine in pediatric embryonal tumors[J].Journal of Clinical Pediatric Surgery,,22():1135-1138.[doi:10.3760/cma.j.cn101785-202208042-008]
Research advances of berberine in pediatric embryonal tumors
- Keywords:
- Berberine; Embryonal Tumors; Neuroblastoma; Hepatoblastoma; Nephroblastoma; Child
- Abstract:
- Huangliansu,also known as berberine,is abenzyl tetra isoquinoline alkaloid.Extracted from Coptis chinensis and other plants,it is also a major ingredient of Huanglian Jiedu Decoction,Zuojin Pills and other traditional Chinese medicine prescriptions.It has proved to have a variety of beneficial biological activities for treating infection,inflammation,cardiovascular diseases,gastrointestinal diseases,neurodegeneration,depression and metabolic disorders.Furthermore,it inhibits the proliferation and promotes apoptosis of esophageal cancer,colonic adenocarcinoma,liver cancer,osteosarcoma,breast cancer and other tumor cells through different mechanisms.Also it may act on a variety of cells of pediatric embryonal tumors,such as neuroblastoma,hepatoblastoma and rhabdomyosarcoma.Thus it is a potential antineoplastic drug.Through a literature review,the authors summarized the drug effects of berberine in embryonal tumors to provide references for follow-up studies.
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Memo
收稿日期:2022-8-24。
通讯作者:董瑞,Email:rdong@fudan.edu.cn