Yang Liyuan,Gu Song,Wang Jing,et al.Research advances of m6A modification in hepatoblastoma[J].Journal of Clinical Pediatric Surgery,,22():1130-1134.[doi:10.3760/cma.j.cn101785-202209040-007]
Research advances of m6A modification in hepatoblastoma
- Keywords:
- Hepatoblastoma; Epigenomics; RNA; m6A Modification
- Abstract:
- As a rare malignant solid tumor in children,hepatoblastoma (HB) is more common in infants aged 0 to 2 years,accounting for 60%-85% of pediatric liver tumors.The prognosis of advanced HB is rather poor.RNA m6A (N6-methyladenosine,m6A) is an ubiquitous epigenetic modification in eukaryotic RNA.It is extensively implicated in various biological processes of tumors.Many studies have demonstrated that m6A modification plays some vital roles in the occurrence and development of HB.Therefore selecting appropriate detection methods and elucidating the molecular mechanisms of m6A modification are significant for proper managements of HB.Summarizing the latest researches of m6A modification in HB,this review examined its potential value of biological markers or therapeutic targets for HB and provided rationales for new management tools for HB.
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Memo
收稿日期:2022-9-24。
基金项目:国家自然科学基金(82072375; 82172357);2021年度国家临床重点专科建设项目[沪卫医(2021)99号]
通讯作者:顾松,Email:gusong@shsmu.edu.cn