Li Chunwang,Yin Yiwei,Cai Qifang,et al.Imaging features of Langerhans cell histiocytosis involving central nervous system and craniofacial bone in children[J].Journal of Clinical Pediatric Surgery,,22():768-772.[doi:10.3760/cma.j.cn101785-202305023-013]
Imaging features of Langerhans cell histiocytosis involving central nervous system and craniofacial bone in children
- Keywords:
- Histiocytosis; Langerhans-Cell; Central Nervous System; Skull; Magnetic Resonance Imaging; Computer Tomo-graphy; Child
- Abstract:
- Objective To explore the characteristic imaging manifestations of Langerhans cell histiocytosis (LCH) involving central nervous system (CNS) and craniofacial bone in children to boost its clinical diagnosis.Methods The imaging findings of 44 patients with LCH involving CNS and craniofacial bones confirmed by pathologic examination were reviewed retrospectively from January 2017 to December 2022.Results Among 44 children with central nervous system-Langerhans cell histiplasia (CNS-LCH), 25 cases had craniofacial osteodegeneration characterized by "bilateral sign" and "button dead bone".Hypothalamic-pituitary lesions were detected with neuropituitary T1WI hypersignal loss (n=16).Dural and pineal lesions were cystic (n=2).Cerebellar lesions displayed slightly longer T1 and slightly longer T2 signals (n=29); Leukoencephalopathy showed slightly longer symmetrical T1 and slightly longer T2 signals (n=2); Perivascular lacunae became dilated with similar circular long T1 and long T2 signals (n=2).Conclusion The major imaging features of LCH involving craniofacial bone are non-sclerotic cystolytic bone destruction and CNS involves gray matter nucleus mass with frequent symmetrical lesions.A definite diagnosis depends upon pathology.
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Memo
收稿日期:2023-05-15。
基金项目:湖南省卫生健康委员会一般指导课题（202209012654）
通讯作者:汤静,Email:274531213@qq.com