Zhu Shili,Wu Lei,He Bin,et al.Efficacy and safety of ciprofol plus remifentanil anesthesia during tethered cord surgery[J].Journal of Clinical Pediatric Surgery,,22():549-553.[doi:10.3760/cma.j.cn101785-202203081-010]
Efficacy and safety of ciprofol plus remifentanil anesthesia during tethered cord surgery
- Keywords:
- Remifentanil; Anesthesia; Tethered Cord Syndrome; Surgical Procedures; Operative; Treatment Outcome; Child
- Abstract:
- Objective To explore whether total intravenous anesthesia with ciprofol combined with remifentanil is safe and effective for tethered cord surgery in children.Methods A total of 66 children with tethered cord syndrome undergoing tethered cord release were randomized into two groups of propofol (p, n=33) and ciprofol (c, n=33).Both groups were induced with the same doses of midazolam, sufentanil and cisatracurium.Endotracheal intubation was performed after attaining intubation conditions.Intraoperative anesthesia was maintained by an intravenous infusion of remifentanil, propofol (group P) and ciprofol (group C).Total doses of anesthetics and time of extubation post-operation were recorded along with heart rate (HR), mean arterial pressure (MAP), finger pulse oxygen saturation (SPO2), depth of anesthesia (BIS) before intubation (T1), after intubation (T2), during skin incision (T3), during epidural incision (T4), at end of surgery (T5) and during extubation (T6).Ramsay score and adverse events were also analyzed.Results There were no significant differences in extubation time[Group P(33.42±1.92) min vs.Group C(33.00±1.76) min], remifentanil volume[Group P(528.84±46.82) μg vs. Group C(504.84±43.16) μg], intravenous infusion volume[Group P(492.7±32.26) mL vs.Group C(450.0±29.27) mL], blood loss volume[Group P(7.73±0.66) mL vs.Group C(7.27±0.69) mL], urine volume[Group P(110.61±13.64) mL vs.Group C(106.78±8.44) mL], HR, MAP and BIS between the two groups. The Ramsay Score in Group P(2.27±0.08) point was significantly higher than that in Group C(2.03±0.05) point The incidence ofinjection pain in Group P(5/28) was significantly higher than that in Group C(0/33). The propofol infusion (287.12±26.15) mg was 4.17 times as much as the ciprofol infusion(68.86±4.92) mg. Conclusion Compared with propofol, the incidence of injection pain and Ramsay Score of ciprofol is lower. Total intravenous anesthesia with ciprofol combined with remifentanil is safe and effective for tethered cord surgery in children.
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Memo
收稿日期:2022-03-25。
基金项目:湖南省卫生健康委科研课题（202204113977）
通讯作者:屈双权,Email:qushuangquan1974@163.com