Shao Jiawen,Zhou Pingjiang,Zhou Lingling,et al.Eosinophilic solid and cystic renal cell carcinoma in children:a case review and literature analysis[J].Journal of Clinical Pediatric Surgery,,22():283-287.[doi:10.3760/cma.j.cn101785-202202058-015]
Eosinophilic solid and cystic renal cell carcinoma in children:a case review and literature analysis
- Keywords:
- Carcinoma; Renal Cell; Tuberous Sclerosis; Oxyphil Cells; Surgical Procedures; Operative; Child
- Abstract:
- Objective To explore the characteristics,diagnosis,treatment and prognosis of eosinophilic solid and cystic renal cell carcinoma in children.Methods Retrospective analysis was performed for clinical data of a child with eosinophilic solid and cystic renal cell carcinoma.The databases of PubMed and Web of Science were searched with the key words of "eosinophilic solid and cystic renal cell carcinoma" or "eosinophilic solid and cystic renal cell cancer" or "eosinophilic solid and cystic renal cell carcinoma" in Wanfang and CNKI.The searching cutoff was up to December 2021.Duplicate literatures were excluded and clinicopathological features and prognosis of this kind of tumor summarized.Results This 9-year-old girl was hospitalized for "detecting a bulge of right abdomen for 3 days".Preoperative imaging examination indicated that right kidney occupied a large space.Then radical resection of giant tumor of right kidney was performed.Pathological diagnosis was eosinophilic solid and cystic renal cell carcinoma in childhood.Immunohistochemical hint:CK20(+);PAX-8(+);CD117 (+);CK7(-).There were no postoperative radiochemotherapy.No recurrence or metastasis occurred during 6-month follow-ups.Six cases from the literature search and this one had a total of 6 children with eosinophilic solid and cystic renal cell carcinoma,including 4 boys and 2 girls with an average age of 14(9-17) years.Two cases had abdominal pain,abdominal mass or pain in both lower extremities and none of them showed clinical features of tuberous sclerosis complex (TSC).The involved side was bilateral (n=1),left (n=1),right (n=2) and non-specified (n=2).Partial (n=1) and radical (n=6) nephrectomy were performed.One child had an involvement of inferior vena cava plus pulmonary embolism and liver metastasis occurred 2 years after adjuvant chemotherapy.TSC gene mutation was detected in 5 cases,all of which were TSC2 gene mutation.There was no tumor recurrence during a median follow-up period of 18(6-132) months.Conclusion As a rare disease in children,eosinophilic solid renal cell carcinoma and cystic renal cell carcinoma generally have non-specific clinical symptoms.Auxiliary examination has no obvious special manifestations,yet it has unique pathological features.Some cases have TSC gene mutation and the prognosis is excellent after radical operation.
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Memo
收稿日期:2022-2-27。
通讯作者:李仲荣,Email:wmclzr@163.com