Li Chunxiu,Zhao Jialian,Tan Linhua.Analysis of risk factors related to hypoglycemia during neonatal surgery[J].Journal of Clinical Pediatric Surgery,,22():67-71.[doi:10.3760/cma.j.cn101785-202106055-013]
Analysis of risk factors related to hypoglycemia during neonatal surgery
- Keywords:
- Hypoglycemia; Physiological Phenomena; Infant; Newborn; Surgical Procedures; Operative; Root Cause Analysis
- Abstract:
- ObjectiveTo explore the intraoperative risk factors associated with neonatal hypoglycemia.MethodsFrom August 2019 to July 2020,a total of 229 neonatal surgical children were recruited.Based upon the level of neonatal intraoperative blood glucose,individuals below 2.2 mmol/L were assigned into hypoglycemia group (n=19) and those above or equal to 2.2 mmol/L into non-hypoglycemic group (n=210).The relevant clinical data of two groups were compared with regards to preoperative profiles (including age,body weight,corrected gestational age,postnatal Apgar score,gestational diabetes mellitus,pregnancy-induced hypertension,neonatal bilirubin concentration,albumin concentration,anemia,hypoproteinemia and parenteral nutrition) and intraoperative findings (including ASA grade,operative duration,operation approach,intraoperative blood glucose,intraoperative blood transfusion volume,infusion volume,blood loss volume,urine volume,dosing of vasoactive drugs and body temperature).ResultsThe corrected gestational age of hypoglycemic and non-hypoglycemic groups was[35(34,38) vs.38(35,39) week],body weight[(2.15±0.68) vs.(2.81±0.74) kg],1 min Apgar score[9(8,10) vs.10(10,10)],incidence of hypoproteinemia[36.84%(7/19) vs.11.90%(25/210)],ASA grade[3(2,3) vs.2(2,2)],intraoperative blood transfusion volume[42.11%(8/19) vs.19.52%(41/210)].The above results showed significant sinter-group tatistical differences (P<0.05).No significant inter-group difference existed in preoperative blood glucose level or operative duration (P>0.05).The results of multivariate analysis indicated that high ASA grade and low corrected gestational age were independent risk factors for neonatal hypoglycemia (P=0.026 and P=0.006).ConclusionOccurrence of intraoperative hypoglycemia in neonates is associated with high ASA grade and low corrected gestational age.
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Memo
收稿日期:2021-06-20。
基金项目:国家儿童健康与疾病临床医学研究中心自主设计项目全国多中心临床研究项目(G20B0009)
通讯作者:谈林华,Email:chtlh@zju.edu.cn