Wang Ruihong,Zuo Jian,Sun Zilan,et al.Correlation between neonatal patent ductus arteriosus and infants of diabetic mothers: a Meta-analysis[J].Journal of Clinical Pediatric Surgery,,21():1067-1074.[doi:10.3760/cma.j.cn101785-202109037-013]
Correlation between neonatal patent ductus arteriosus and infants of diabetic mothers: a Meta-analysis
- Keywords:
- Infant; Newborn; Ductus Arteriosus; Patent; Maternal Nutritional Physiological Phenomena; Diabetes; Gestational
- Abstract:
- Objective To explore the correlation between neonatal patent ductus arteriosus (PDA) and infants of diabetic mothers (IDM) through a Meta-analysis to provide theoretical rationales for preventing neonatal PDA.Methods The databases of Web of Science, PubMed, Scopus, Embase, Cochrane, ProQuest, OVID, CNKI, WanFang, VIP and SinoMed were searched from the inceptions to August 2021.The search terms included patent ductus arteriosus, ductus arteriosus, patent of arterious ductus, diabetes, diabetes mellitus, hyperglycemia, maternal hyperglycemia and maternal diabetes mellitus.Two independent researchers conducted literature screening, data extracting and quality evaluations.The neonates were assigned into two groups of PDA and no-PDA according to the diagnosis.Subgroup analysis was conducted according to case locality, study design and type of diabetes.And Stata 14.0 was utilized for statistical prcoessing.Results Eleven studies with a total of 1 014 399 samples were included.Meta-analysis indicated that the prevalence of IDM was 1.25 folds higher in neonatal PDA group than that in neonatal non-PDA group.The difference was not statistically significant (RR=1.25, 95%CI:0.97-1.61, P=0.086).Subgroup analysis revealed no significant difference in neonatal PDA or IDM in Asian subgroups (RR=1.05, 95%CI:0.92-1.21, P=0.471) and the prevalence of IDM was 2.45 folds in neonatal PDA group than that in neonatal no-PDA group (RR=2.45, 95%CI:1.98-3.02, P<0.001).Comparing cohort study, case-control study, gestational diabetes mellitus (GDM) and pregestational diabetes mellitus (PGDM) subgroups revealed no significant difference in neonatal PDA or IDM.The sensitivity of each study was robust and publication bias stable.Conclusion No statistically significant correlation exists between IDM and neonatal PDA in overall studies.
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Memo
收稿日期:2021-09-22。
基金项目:国家重点研发计划（2016YFC1301901）
通讯作者:孙子兰,Email:411474990@qq.com