Liang Zhuangzhuang,Zhao Heng,Wang Jiajia,et al.Effect of Ki-67 expression on prognosis of pediatric medulloblastoma[J].Journal of Clinical Pediatric Surgery,,21():746-751.[doi:10.3760/cma.j.cn101785-202105017-008]
Effect of Ki-67 expression on prognosis of pediatric medulloblastoma
- Keywords:
- Medulloblastoma/DI; Biomarkers; Tumor; Medulloblastoma/SU; Treatment Outcome; Child
- Abstract:
- Objective To explore the clinical characteristics and survival profiles of pediatric medulloblastoma and examine the effect of Ki-67 on its prognosis.Methods From January 2006 to December 2015,a total of 67 postoperatively pathologically confirmed MB children were recruited.Their 5-year overall survival (OS) and progression-free survival (PFS) were calculated by Kaplan-Meier method.Univariate analysis was performed by Log-rank test and multivariate analysis by Cox regression.The relationship was examined between clinical characteristics of MB,treatments and the expression of Ki-67 on the prognosis.Results The average Ki-67 index was (34.85±16.72%).There were 37 cases in low-expression of Ki-67 group (<35%),5-year PFS (70.27%,26/37) and OS (51.35%,19/37);30 cases in high-expression of Ki-67 group (≥ 35%),5-year PFS (40.00%,12/30) and OS (36.67%,11/30).Cox proportional risk regression model showed that a high expression of Ki-67 was an independent factor for MB survival in children (P=0.04).However,no statistically significant difference existed in postoperative metastasis or recurrence.Conclusion Ki-67 is an independent prognostic biomarker for pediatric MB.
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Memo
收稿日期:2021-5-12。
基金项目:上海市科委(19411952100)
通讯作者:马杰,Email:majie@xinhuamed.com.cn