Xu Chenchen,Liu Zhenjiang.Research advances in genetics of congenital talipes equinovarus[J].Journal of Clinical Pediatric Surgery,,21():725-730.[doi:10.3760/cma.j.cn101785-202008030-005]
Research advances in genetics of congenital talipes equinovarus
- Keywords:
- Equinus Deformity/CN; Equinus Deformity/ET; Genes/GE
- Abstract:
- Congenital talipes equinovarus (CTEV) has been one of the most common birth defects of skeletal muscle in children.Its pathogenesis is still elusive.Different theories cover nerve cell injury,muscle abnormality,vascular defect,intrauterine restriction,genetic factors,idiopathic congenital malformation,gene environment interaction,bone dysplasia,extracellular matrix abnormality,molecular transport and metabolic abnormality.Genetic factors play an important role in the etiology of CTEV.However,no major pathogenic gene has been identified.It is generally believed that environmental and genetic factors may interact.This review summarized the latest researches of CTEV pathogenic genes.
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Memo
收稿日期:2020-8-13。
基金项目:首都儿科研究所所级课题(FX-2020-06)
通讯作者:刘振江,Email:lzjsdd@163.com