Wei Xinzhe,Sun Chao,Dong Chong,et al.Predictive value of eosinophil percentage during an early acute rejection after liver transplantation in children of different ages[J].Journal of Clinical Pediatric Surgery,,21():420-424.[doi:10.3760/cma.j.cn101785-202111020-005]
Predictive value of eosinophil percentage during an early acute rejection after liver transplantation in children of different ages
- Abstract:
- Objective To explore the correlation between the percentage of eosinophils in peripheral blood and the occurrence of acute rejection and evaluate the predictive value of the percentage of eosinophils in blood for early rejection in children after liver transplantation (LT). Methods From January 201 9 to December 2020, clinical data were retrospectively reviewed for children undergoing LT. They were divided into two groups of acute rejection and non-rejection based upon the pathological findings of liver biopsy within 6 months. The mean percentage of early postoperative eosinophil was compared between two groups. With a con- tour graph, repeated measurement ANOVA was performed for determining the correlation with the occurrence of acute rejection. And receiver operating characteristic (ROC) curve was plotted for determining the critical mean percentage of eosinophil during an early stage of rejection. Results A total of 396 children undergoing LT were recruited. The postoperative incidence of early acute rejection was 1 7. 93% (71/396). After stratifi- cation by age (0~1 y/1-6 y/> 6 y), the mean percentage of eosinophil during an early postoperative period was significantly correlated with the occurrence of rejection within 6 months in children aged 0~1 years, but not in children of other ages. The results of repeated measurement indicated that the mean percentage of eosin- ophil in acute rejection group was significantly higher than that in non-rejection group among children aged 0~1 (F=25. 38, P < 0. 001). ROC curve of the mean percentage of eosinophil predicting the rejection reac- tion at 1~7 days showed that its area under curve (AUC) was 0. 743 (95% CI:0. 668-0. 81 7) with a sen- sitivity of 65%, a specificity of 74%, a critical value of 3. 23%, a positive predictive value of 31. 1 8% and a negative predictive value of 91. 05%. Conclusion Among pediatric LT recipients, the mean percentage of eosinophil at Day 1-7 has certain predictive value for the occurrence of acute rejection after LT in children aged 0~1 years. With high specificity and negative predictive value, it may be utilized as an indicator of early risk screening.
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Memo
收稿日期:2021-11-10。
基金项目:天津市重点学科（专科）建设项目
通讯作者:高伟,Email:gao-wei@medmail.com.cn