Hu Mingyao,Shang Wenjun,Feng Yonhua,et al.Effect of glucocorticoids withdrawal on growth curve after pediatric renal transplantation[J].Journal of Clinical Pediatric Surgery,,21():415-419.[doi:10.3760/cma.j.cn101785-202203055-004]
Effect of glucocorticoids withdrawal on growth curve after pediatric renal transplantation
- Keywords:
- Renal Transplantation; Immunosuppression; Glucocorticoids; Growth Hormone; End- stage Renal Disease; Growth Disorders; Growth Charts; Comparative Study; Child
- Abstract:
- Objective To explore the trend of growth and development of children after renal transplan- tation and examine the effect of hormone withdrawal on growth curve. Methods From May 2013 to March 2021, a retrospective analysis was performed for clinical data of 214 children undergoing renal transplantation. According to whether or not hormone withdrawing within 3 months after surgery, it was divided into two groups of hormone withdrawal (n=142) and non-withdrawal (n=72). The curve of growth and development were com- pared between two groups before and after hormone withdrawal. Results Preoperative height for age Z-score (HAZ) was (-1. 60 ±1. 48) and (-1. 44 ±1. 38) without statistical difference (P=0. 539). At Year 1 post-operation, HAZ was (-0. 95 ±1. 31) and (-0. 51 ±1. 10). And the difference was statistically signifi- cant (P=0. 046). After renal transplantation, no inter-group difference existed in ΔHAZ before hormone with- drawal. The trend of ΔHAZ in hormone withdrawal group was higher than that in hormone non-withdrawal group within 3-6 months[(0. 124 ±0. 158) vs. (0. 083 ±0. 123), P=0. 069] and it was also significantly higher in hormone withdrawal group than that in hormone non-withdrawal group at 6 months (P=0. 016). Conclusion Children with end-stage renal disease (ESRD) have varying degrees of developmental delay before sur- gery. After renal transplantation, most defects become compensated. And rate of height development varies at dif- ferent timepoints. Withdrawal of hormones before a peak of postoperative catch-up growth has a positive effect on long-term development of postoperative children.
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Memo
收稿日期:2022-3-16。
基金项目:河南省省部共建重点项目（SB201901004）
通讯作者:丰贵文,Email:fengguiwen@medmail.com.cn