Gao Runnan,Zhu Haitao,Shen Chun.Research advances in models of necrotizing enterocolitis in vivo and in vitro[J].Journal of Clinical Pediatric Surgery,,21():331-335.[doi:10.3760/cma.j.cn101785-202009024-007]
Click Copy

Research advances in models of necrotizing enterocolitis in vivo and in vitro

References:

[1] Zani A,Pierro A.Necrotizing enterocolitis:controversies and challenges[J].F1000 Res,2015,4pii:F1000FacultyRev-1373.DOI:10.12688/f1000research.6888.1.
[2] Stoll BJ,Hansen NI,Bell EF,et al.Trends in care practices,morbidity,and mortality of extremely preterm neonates,1993-2012[J].J Am Med Assoc,2015,314:1039-1051.DOI:10.1001/jama.2015.10244.
[3] Ni?o DF,Sodhi CP,Hackam DJ.Necrotizing enterocolitis:new insights into pathogenesis and mechanisms[J].Nat Rev Gastroenterol Hepatol,2016,13:590-600.DOI:10.1038/nrgastro.2016.119.
[4] 吕志宝,盛庆丰.新生儿坏死性小肠结肠炎的病因与诊治研究进展[J].临床小儿外科杂志,2019,18(5):352-355.DOI:10.3969/j.issn.1671-6353.2019.05.003. Lü ZB,Sheng QF.Advances in the etiology,diagnosis and treatment of neonatal necrotizing enterocolitis[J].Clinical Pediatric Surgery,2019,18(5):352-355.DOI:10.3969/j.issn.1671-6353.2019.05.003.
[5] Fitzgibbons SC,Ching Y,Yu D,et al.Mortality of necrotizing enterocolitis expressed by birth weight categories[J].J Pediatr Surg,2009,44:1072-1075.DOI:10.1016/j.jpedsurg.2009.02.013.
[6] Li B,Lee C,Martin Z,et al.Intestinal epithelial injury induced by maternal separation is protected by hydrogen sulfide.J Pediatr Surg,Jan2017;52(1):40-44.DOI:10.1016/j.jpedsurg.2016.10.013
[7] Lee C,Minich A,Li B,et al.Influence of stressfactors on intestinal epithelial injury and regeneration[J].Pediatr Surg Int,2018,34(2):155-160.DOI:10.1007/s00383-017-4183-3.
[8] Ling X,Linglong P,Weixia D,et al.Protective effects of bifido-bacterium on intestinal barrier function in LPS-induced enterocyte barrier injury of Caco-2 monolayers and in a rat NEC model[J].PLoS One,2016,11(8):e0161635.DOI:10.1371/journal.pone.0161635.
[9] Bergmann KR,Liu SX,Tian R,et al.Bifidobacteria stabilize cla-udins at tight junctions and prevent intestinal barrier dysfunction in mouse necrotizing enterocolitis[J].Am J Pathol,2013,182(5):1595-1606.DOI:10.1016/j.ajpath.2013.01.013.
[10] Lin HC,Hsu CH,Chen HL,et al.Oral probiotics prevent necrotizing enterocolitis in very low birth weight preterm infants:a multicenter,randomized,controlled trial[J].Pediatrics,2008,122(4):693-700.DOI:10.1542/peds.2007-3007.
[11] Sato T,Vries RG,Snippert HJ,et al.Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche[J].Nature,2009,459(7244):262-265.DOI:10.1038/nature07935.
[12] Dedhia PH,Bertaux-Skeirik N,Zavros Y,et al.Organoid models of human gastrointestinal development and disease[J].Gastroenterology,2016,150(5):1098-1112.DOI:10.1053/j.gastro.2015.12.042.
[13] Schweiger PJ,Jensen KB.Modeling human disease using organotypic cultures[J].Curr Opin Cell Biol,2016,43:22-29.DOI:10.1016/j.ceb.2016.07.003.
[14] Kretzschmar K,Clevers H.Organoids:modeling development and the stem cell niche in a dish[J].Dev Cell,2016,38(6):590-600.DOI:10.1016/j.devcel.2016.08.014.
[15] McElroy SJ,Castle SL,Bernard JK,et al.The ErbB4 ligand neuregulin-4 protects against experimental necrotizing enterocolitis[J].Am J Pathol,2014,184(10):2768-2778.DOI:10.1016/j.ajpath.2014.06.015.
[16] Sodhi CP,Neal MD,Siggers R,et al.Intestinal epithelial toll-like receptor 4 regulates goblet cell development and is required for necrotizing enterocolitis in mice[J].Gastroenterology,2012,143(3):708.e5-718.e5.DOI:10.1053/j.gastro.2012.05.053.
[17] Li B,Lee C,Cadete M,et al.Neonatal intestinal organoids as an ex vivo approach to study early intestinal epithelial disorders[J].Pediatr Surg Int,2019,35(1):3-7.DOI:10.1007/s00383-018-4369-3.
[18] Gao R,Zhang R,Qian T,et al.A comparison of exosomes derived from different periods breast milk on protecting against intestinal organoid injury[J].Pediatric Surgery International,2019,35(12):1363-1368.DOI:10.1007/s00383-019-04562-6.
[19] Wu RY,Li B,Koike Y,et al.Human milk oligosaccharides increase mucin expression in experimental necrotizing enterocolitis[J].Mol Nutr Food Res,2019,63(3):e1800658.DOI:10.1002/mnfr.201800658.
[20] Ares GJ,Buonpane C,Yuan C,et al.A novel human epithelial enteroid model of necrotizing enterocolitis[J].J Vis Exp,2019,10(146):91-94.DOI:10.3791/59194.
[21] Finkbeiner SR,Hill DR,Altheim CH,et al.Transcriptome-wide analysis reveals hallmarks of human intestine development and maturation in vitro and in vivo[J].Stem Cell Reports,2015,4(6):1140-1155.DOI:10.1016/j.stemcr.2015.04.010.
[22] 欧静,徐珍妮,刘登群,等.3D培养体系中不同肠上皮细胞株形成肠类器官潜能的比较及应用[J].第三军医大学学报,2020,42(1):31-38.DOI:10.16016/j.1000-5404.201907198. Ou J,Xu ZN,Liu DQ,et al.Potential capacities of different intestinal epithelial cell lines for forming enteroids in 3D culture system:comparisons and applications[J].J Third Mil Med Univ,2020,42(1):31-38.DOI:10.16016/j.1000-5404.201907198.
[23] Almeqdadi M,Mana MD,Roper J,et al.Gut organoids:mini-tissues in culture to study intestinal physiology and disease[J].Am J Physiol Cell Physiol,2019,317(3):C405-C419.DOI:10.1152/ajpcell.00300.2017.
[24] Barlow B,Santulli TV,Heird WC,et al.An experimental study of acute neonatal enterocolitis-the importance of breast milk[J].J Pediatr Surg,1974,9(5):587-595.DOI:10.1016/0022-3468(74)90093-1.
[25] Nadler EP,Dickinson E,Knisely A,et al.Expression of inducible nitric oxide synthase and interleukin-12 in experimental necrotizing enterocolitis[J].J Surg Res,2000,92:71-77.DOI:10.1006/jsre.2000.5877.
[26] Zani A,Eaton S,Leon FF,et al.Captopril reduces the severity of bowel damage in a neonatal rat model of necrotizing enterocolitis[J].J Pediatr Surg,2008,43(2):308-314.DOI:10.1016/j.jpedsurg.2007.10.022.
[27] Ford HR,Avano[KG-1.1mm]g[DD (-1*9] [HT6.]ˇlu A,Boechat PR,et al.The microenvironment influences the pattern of bacterial translocation in formula-fed neonates[J].J Pediatr Surg,1996,31(4):486-489.DOI:10.1016/s0022-3468(96)90480-7.
[28] Zhang BH,Yu HG,Sheng ZX,et al.The therapeutic effect of recombinant human trefoil factor 3 on hypoxiainduced necrotizing enterocolitis in immature rat[J].Regul Pept,2003,116(1-3):53-60.DOI:10.1016/s0167-0115(03)00177-0.
[29] Jilling T,Simon D,Lu J,et al.The roles of bacteria and TLR4 in rat and murine models of necrotizing enterocolitis[J].J Immunol,2006,177(5):3273-3282.DOI:10.4049/jimmunol.177.5.3273.
[30] Zani A,Zani-Ruttenstock E,Peyvandi F,et al.A spectrum of intestinal injury models in neonatal mice[J].Pediatr Surg Int,2016,32(1):65-70.DOI:10.1007/s00383-015-3813-x.
[31] Qureshi FG,Leaphart C,Cetin S,et al.Increased expression and function of integrins in enterocytes by endotoxin impairs epithelial restitution[J].Gastroenterology,2005,128(4):1012-1022.DOI:10.1053/j.gastro.2005.01.052.
[32] Mollen KP,Gribar SC,Anand RJ,et al.Increased expression and internalization of the endotoxin coreceptor CD14 in enterocytes occur as an early event in the development of experimental necrotizing enterocolitis[J].J Pediatr Surg,2008,43(6):1175-1181.DOI:10.1016/j.jpedsurg.2008.02.050.
[33] Tian R,Liu SX,Williams C,et al.Characterization of a necrotizing enterocolitis model in newborn mice[J].Int J Clin Exp Med,2010,3(4):293-302.
[34] Ginzel M,Feng X,Kuebler JF,et al.Dextran sodium sulfate (DSS) induces necrotizing enterocolitis-like lesions in neonatal mice[J].PLoS One,2017,12(8):e0182732.DOI:10.1371/journal.pone.0182732.
[35] Zhang C,Sherman MP,Prince LS,et al.Paneth cell ablation in the presence of Klebsiella pneumoniae induces necrotizing enterocolitis (NEC)-like injury in the small intestine of immaturemice[J].Dis Model Mech,2012,5(4):522-532.DOI:10.1242/dmm.009001.

Memo

收稿日期:2020-09-14;改回日期:。
基金项目:国家自然科学基金面上项目(81873849);上海市自然科学基金面上项目(22ZR1408600);国家儿童医学中心青年临床科学家项目(EK112520180306)
通讯作者:沈淳,Email:chunshen@fudan.edu.cn

Last Update: 1900-01-01