Li Lingqing,Xiao Ting,Chen Zheng.Safety and efficacy of intravenous ibuprofen for treatment of pain in children after polydactylectomy[J].Journal of Clinical Pediatric Surgery,,21():272-277.[doi:10.3760/cma.j.cn101785-202112013-013]
Safety and efficacy of intravenous ibuprofen for treatment of pain in children after polydactylectomy
- Keywords:
- Polydactyly/SU; Anesthesia and Analgesia/MT; Ibuprofen/AD; Ibuprofen/AE; Validation Studies
- Abstract:
- Objective To observe the analgesic efficacy and adverse reactions of sufentanil combined with intravenous ibuprofen for children who underwent polydactylectomy and explore the safety and effectiveness of intravenous ibuprofen for perioperative analgesia in children.Methods A total of 120 children diagnosed with congenital thumb anomalies and undergoing polydactylectomy, osteotomy and internal fixation with Kirschner wire from September 2020 to September 2021 were selected as study subjects.Snfentani 0.3 μg/kg and propofol 2-4 mg/kg were used for anesthesia induction.The patients were divided into the ibuprofen group (n=60 and the control group (n=60) according to whether intravenous ibuprofen was used after surgery.Both groups were given patient controlled intravenous analgesia (PCIA) after surgery (sufentanil 0.04 μg·kg-1·h-1 infusion continuously).The Ibuprofen group received a single dose of 10 mg/kg intravenous ibuprofen every 8 h, until 48 h after surgery while the control group received the same dose of normal saline simultaneously.The analgesic efficacy and adverse reactions of the two groups were evaluated.Results The FLACC scores at 2 h, 8 h, 24 h and 48 h after operation in ibuprofen group were significantly lower than that of the control group (P<0.01);the pressing times of PCA was fewer in the ibuprofen group (Z=-6.161, P<0.01);the mean value of the postoperative consumption of sufentanil in the ibuprofen and control group was 18.01 μg and 24.05 μg respectively, and the difference was statistically significant (t=-7.289, P<0.01);the percentage of requiring rescue analgesia was 6.7%(4/60) in ibuprofen group and 20.0%(12/60) in the control group, and the difference was statistically significant (χ2=4.615, P=0.032);the scores of postoperative analgesic satisfaction and sleep satisfaction of patients in the ibuprofen group were significantly higher than those in the control group (P<0.01).There was no significant difference in the incidence of adverse reactions such as dizziness, vomiting, drowsiness, and skin pruritus between the two groups(P>0.05);the incidence of fever in the control group was higher than that of the ibuprofen group, and the difference was statistically significant(P<0.05).Conclusion It is safe to use intravenous ibuprofen in pediatric patients.The combined use of intravenous ibuprofen after surgery can achieve better analgesic effects than single use of sufentanil, and reduce the dosage of opioids.So intravenous ibuprofen is a safe and effective option for postoperative analgesia in children.
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Memo
收稿日期:2021-12-05。
基金项目:湖南省科技厅临床医疗技术创新引导计划（2018sk50407）
通讯作者:陈政,Email:czok@sina.com