Ma Yue,Wang Shan,Li Changchun,et al.Single-center analysis of clinical features and prognosis of neuroblastoma children with bone metastasis[J].Journal of Clinical Pediatric Surgery,,21():115-120.[doi:10.3760/cma.j.cn.101785-202105011-004]
Single-center analysis of clinical features and prognosis of neuroblastoma children with bone metastasis
- Keywords:
- Neuroblastoma/CO; Neuroblastoma/CL; Neoplasm Metastasis; Prognosis; Child
- Abstract:
- Objective To analyze the clinical features and prognostic factors of neuroblastoma (NB)children with bone metastasis.Methods The clinical data of 97 cases of NB children with bone metastasis treated in the Department of surgical Oncology, Children’s Hospital of Chongqing Medical University from December 2013 to December 2020 were retrospectively analyzed to compare the influence of different factors on the prognosis of the children.Results Among the 97 cases, there were 68 males and 29 females.The male to female ratio was 2.4:1, and the median age was 49.4 months.The common first symptoms were fever (48.5%), bone pain (39.2%), abdominal pain or abdominal distension (29.9%).The children with bone metastasis were prone to multiple bone metastasis (62.9%) and bone marrow metastasis (73.2%).The overall prognosis of NB children with bone metastasis was poor, with a 1-year overall survival rate of 93.6% and a 5-year overall survival rate of 20.2%.Survival analysis showed that female children, patients with multiple bone metastases, tumors located in the abdomen, LDH value greater than 660U/L at first diagnosis, and intraoperative tumor residue often suggested poor prognosis, among which surgical resection range was an independent prognostic factor.Conclusion NB children with bone metastasis have diverse clinical manifestations, and their prognosis is affected by many factors, and tumor recurrence or progression is the main cause of death.For such children, it is recommended that the tumor be removed as completely as possible intraoperatively to improve the prognosis.
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Memo
收稿日期:2021-05-10。
基金项目:国家重点研发计划（2018YFC1313000）
通讯作者:王珊,Email:wangshan778@163.com