Lin Defu,Huang Yangyue,Sun Ning,et al.Correlation analysis of low birth weight and hypospadias in twins[J].Journal of Clinical Pediatric Surgery,,21():7-12.[doi:10.3760/cma.j.cn.101785-202010025-002]
Correlation analysis of low birth weight and hypospadias in twins
- Keywords:
- Hypospadias/ET; Twins; Infant; Extremely Low Birth Weight; Infant; Very Low Birth Weight
- Abstract:
- Objective To expolre the relationship between birth weight and the hypospadias in twins. Methods Retrospective analysis was conducted for 42 pairs of twins with hypospadias from January 2013 to January 2020.The twins’ birth weight were recorded.According to the location of urethral opening, hypospadias can be divided into 4 types:type Ⅰ is glans penis and coronary groove hypospadias, type Ⅱ is penile hypospadias, type Ⅲ is scrotal hypospadias, and type IV is perineal hypospadias.The whole blood samples of all twins were examined by whole exon sequencing and bioinformatics analysis The examination confirmed 23 pairs of monozygotic twins and 19 pairs of dizygotic twins. Results There were 54 cases of hypospadias in 42 pairs of twins, including 6 type I hypospadias, 20 type Ⅱ hypospadias, 22 type Ⅲ hypospadias and 6 type Ⅳ hypospadias.Monozygotic twins were more likely to have hypospadias than dizygotic twins (OR=6.5, 95%CI:1.217~35.124).The correlation analysis of low birth weight and hypospadias in twins showed that low birth weight was a risk factor for hypospadias (OR=4.124, 95%CI:1.588~10.710, P=0.004).The risk of hypospadias in low birth weight infants was 5.885 times higher than that of normal weight infants (OR=5.885, 95%CI:1.082~32.014, P=0.040), while the risk of hypospadias in extremely low birth weight infant was 3.804 times higher (OR=3.804, 95%CI:1.406~10.293, P=0.009).Among the 13 pairs of discordant monozygotic twins, the birth weights of those with and without hypospadias were (1 805±437) g and (2 598±582) g respectively, and the difference was statistically significant (t=3.929, P=0.001).Low birth weight (OR=25.955, 95%CI:2.069~325.556, P=0.012) was a risk factor for hypospadias in discordant monozygotic twins.For the 17 pairs of discordant dizygotic twins, the birth weights of those with and without hypospadias were (2 077±677) g and (2 527±478) g respectively with statistically significant difference (t=2.242, P=0.032).Low birth weight (OR=3.929, 95%CI:1.041~13.837, P=0.044) was a risk factor for hypospadias in discordant dizygotic twins.The use of progesterone during pregnancy did not increase the risk of hypospadias in twins (OR=1.458, 95%CI:0.572 to 3.853, P=0.416). Conclusion The one with lower birth weight in monozygotic or dizygotic twins is more likely to develop hypospadias.
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Memo
收稿日期:2020-10-24。
基金项目:中国国家重点研发计划（2016YFC1000807）；北京市医院管理局儿科学科协同发展中心儿科专项（XTYB201823）
通讯作者:宋宏程,Email:songhch1975@126.com