Zhou Guanglun,Sun Junjie,Yin Jianchun,et al.Analysis of pathogens and clinical features of neuropathic bladder with urinary tract infection in children[J].Journal of Clinical Pediatric Surgery,,20():1021-1025.[doi:10.12260/lcxewkzz.2021.11.005]
Analysis of pathogens and clinical features of neuropathic bladder with urinary tract infection in children
- Keywords:
- Neurogenic Bladder; Urinary Tract Infection; Bacteria; Fungi; Child
- CLC:
- R726.945;R378;R379
- Abstract:
- Objective To assess the clinical features, pathogenic distributions and drug resistance of neuropathic bladder with urinary tract infection in children so as to provide rationales for clinical diagnosis and treatment of the disease. Methods From January 2010 to December 2019, clinical data were retrospectively reviewed for 33 hospitalized children of neuropathic bladder with urinary tract infection. Results There were 17 boys and 16 girls with an age range of 1-156 months. Repeated infections thrice and more occurred in 28 cases. One case had 8 bouts of infection. Fever was the most common. Elder children had frequent & painful urination and abdominal pain. A total of 87 strains were cultured from the samples from 33 children, including 63 strains of Gram-negative bacteria and 17 strains of Gram-positive bacteria. The drug resistant rates of Gram-negative bacteria to ampicillin and cefuroxime sodium were both >78%. The sensitive rates to piperacillin tazobactam and meropenem were >88%. Thirty-three cases were cured by piperacillin tazobactam and another 13 cases cured by switching cefuroxime sodium to piperacillin tazobactam. Conclusion Clinical manifestations of neuropathic bladder with urinary tract infection are non-typical and repeated infections occur frequently. The resistance rate to penicillin or cephalosporins is high. The drug resistance rate of piperacillin tazobactam is low with a decent prognosis.
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Memo
收稿日期:2020-11-24。
基金项目:国家自然科学基金（编号：U1904208）
通讯作者:李守林,Email:lishoulinsz@126.com