Li Weiqing,Dong Zilong,Chen Qian.Research advances in molecular subgroups and risk stratifications of medulloblastoma[J].Journal of Clinical Pediatric Surgery,,20():687-692.[doi:10.12260/lcxewkzz.2021.07.018]
Research advances in molecular subgroups and risk stratifications of medulloblastoma
- Keywords:
- Medulloblastoma; Molecular Subgroups; Risk Stratification; Prognosis
- CLC:
- R730.56;R726.12
- Abstract:
- In recent years,molecular subgrouping of medulloblastoma (MB) has provided relatively accurate information for its prognosis.Currently DNA methylation profiling is recommended for replacing gene expression analysis as a gold standard for determining MB subgroup status and substructure within subgroups.For further improving the prognosis of MB children,both domestic and foreign scholars redefined risk stratifications,updated treatment strategies and achieved excellent outcomes.This review summarized the characteristics of each molecular subgroup and its prognostic risk stratification.
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Memo
收稿日期:2020-05-15。
通讯作者:陈乾,Email:chenqian68@126.com