Han Jianyu,Chang Xiaofeng,Qin Hong,et al.Analysis of curative effect of BEP chemotherapy in endodermal sinus tumor of vagina[J].Journal of Clinical Pediatric Surgery,,20():557-561,575.[doi:10.12260/lcxewkzz.2021.06.010]
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Analysis of curative effect of BEP chemotherapy in endodermal sinus tumor of vagina

Journal of Clinical Pediatric Surgery[ISSN:1671-6353/CN:43-1380/R] volume: 第20卷 Number: 2021 06 Page: 557-561,575 Column: 儿童肿瘤 Date of publication: 2021-06-15
Author(s):
Han Jianyu1;  Chang Xiaofeng1;  Qin Hong1;  Yang Wei1;  Han Wei1;  Cheng Haiyan1;  He Lejian2;  Wang Huanmin1
1. Department of Pediatric Oncological Surgery, National Center for Children’s Health, Beijing Children’s Hospital, Capital Medical University, Beijing 100045, China;
2. Department of Pathology, National Center for Children’s Health, Beijing Children’s
Keywords:
Vaginal Neoplasms; Neoplasms;  Germ Cell and Embryonal; Antineoplastic Combined Chemotherapy Protocols; Treatment Outcome; Child
CLC:
R737.34;R979.1;R730.265.82
DOI:
10.12260/lcxewkzz.2021.06.010
Abstract:
Objective To explore the therapeutic efficacy and prognosis of BEP chemotherapy in children with vaginal endodermal sinus tumor (EST).Methods A retrospective review was conducted for medical records of children with vaginal EST from 2008 to 2020.The clinical manifestations,age of onset,tumor size and distant metastasis were recorded.All cases were diagnosed by preoperative pathological examinations.Follow-up methods included ultrasonography,computed tomography (CT) and serum level of alpha fetoprotein (AFP).The standard BEP chemotherapeutic regimen of bleomycin,etoposide and cisplatin was adopted.Prognostic evaluations were based upon the WHO criteria of general solid tumor efficacy:complete remission (CR),partial remission (PR),disease stability (SD),disease progression (PD).Results Twelve children were recruited with a median age of 14.5(9-21) years.The average tumor size was 4.1 cm.One child had iliac fossa lymph node metastasis.After an average of 4 chemotherapeutic courses,they achieved CR (n=7,58.3%) and PR (n=5,41.7%).Among 5 PR children,3 cases were operated for CR and postoperative pathology confirmed necrotic tumor cells.Two children turning down surgery received more cycles of BEP chemotherapy.One case achieved CR at Month 7 while another with lymph node metastasis maintained in PR.The elevated AFP returned to a normal level after an average of 2.8 cycles of chemotherapy.During a mean follow-up period of 101 months,there was no recurrence.Conclusion Vaginal EST may yield an excellent outcome through a standardized chemotherapy.As a first-line treatment protocol,BEP has an obvious efficacy.Most children can achieve CR and there is no recurrence during long-term follow-ups.For PR children,surgery can effectively remove residual nodules and prevent recurrence.

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Memo

收稿日期:2020-05-25;。
通讯作者:王焕民,Email:wanghuanmin@bch.com.cn

Last Update: 1900-01-01