Hu Zhen,Chen Wei,Xie Yanping,et al.Clinical characteristics and surgical treatment strategy of pediatric disembryoplastic neuroepithelial tumor[J].Journal of Clinical Pediatric Surgery,,20():415-419.[doi:10.12260/lcxewkzz.2021.05.004]
Clinical characteristics and surgical treatment strategy of pediatric disembryoplastic neuroepithelial tumor
- Keywords:
- Brain Neoplasms; Disembryoplastic Neuroepithelial Tumor/SU; Epilepsy/SU; Treatment Outcome; Child
- CLC:
- R739.4;R726.1;R742.1
- Abstract:
- Objective To summarize the clinical features of disembryoplastic neuroepithelial tumor (DNT) and discuss its surgical strategies.Methods From January 2015 to June 2020,a total of 14 DNT children undergoing operations at Department of Neurosurgery,Guangzhou Women & Children’s Medical Center were retrospectively analyzed.There were 11 boys and 3 girls with an average age of 4.64(1/3-13) years.Epileptic seizures were focal (n=9) and general (n=5).The average course of disease was 10.46 moths (1 week to 3 years).Gender,age,duration of disease,seizure type,imaging studies,surgical approach,extent of tumor resection,postoperative pathology and efficacy were thoroughly analyzed.Results Imaging showed that tumor involved the lobes of temporal (n=9),frontal (n=3) and parietal (n=1).Detailed preoperative evaluations were performed.Cortical electroencephalography (ECoG) monitoring was performed intraoperatively for assisting in the determination of epileptic foci (n=12),simple tumor resection (n=1) and major tumor resection (n=1).There were postoperative intracranial infection (n=4),lowered strength of contralateral limb muscle and survival (n=14).Postoperative pathological examinations indicated simple DNT (n=5) and complex DNT (n=9).The average follow-up period was 2.14(7/12-5) years.According to the Engel classification scheme of postoperative curative effect,the Engel levels were Ⅰ (n=13,92.86%) and Ⅳ (n=1,7.14%).Conclusion DNT is a common cause of childhood epilepsy and drug treatment is often ineffective.Surgery is both safe and effective.The concept of surgery for epilepsy and intraoperative ECoG are helpful to determine the range of epileptic focus and improve the control outcomes of postoperative epilepsy.
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Memo
收稿日期:2021-01-03。
基金项目:国家自然科学基金（编号：81703011）
通讯作者:许新科,Email:sjwkxxk@163.com