Chen Hongkun,Zhang Dasen.Clinical significance of serum levels of mir-223 and inflammatory factors in children with Hirschs-prung’s disease[J].Journal of Clinical Pediatric Surgery,,20():359-364.[doi:10.12260/lcxewkzz.2021.04.011]
Clinical significance of serum levels of mir-223 and inflammatory factors in children with Hirschs-prung’s disease
- Keywords:
- Hirschsprung Disease/DI; Hirschsprung Disease/CO; Enterocolitis; mir-223; Inflammatory Factors
- CLC:
- R574;R726
- Abstract:
- Objective To explore the clinical significance of serum levels of mir-223 and inflammatory factors in children with Hirschsprung’s disease (HD).Methods From January 2017 to August 2018, 66 children undergoing radical operations for HD were selected as study subjects while another 70 healthy counterparts in the same period were selected as healthy group according to the baseline data.The observation group were further divided into HAEC group (n=20) and non-AEC group (n=46).The serum levels of mir-223, TNF-α, IL-6 and IL-8 were compared and analyzed before and after operation and analyses of multiple factor and ROC curve of HAEC were conducted.Results The serum levels of mir-223, TNF-α, IL-6 and IL-8 in observation group were significantly higher than those in healthy group (P<0.05) while those in HAEC group were significantly higher than those in non-HAEC group (P<0.05).Serum levels of mir-223, TNF-α, IL-6 and IL-8 were independent risk factors of HAEC (P<0.05).The AUC of HAEC was 0.889, 0.826, 0.678 and 0.657 as predicted by mir-223, IL-6, TNF-α and IL-8 respectively.The corresponding cutoff values were 3.90 (sensitivity=86.70%, specificity=80.00%), 34.20 (sensitivity=83.30%, specificity=75.00%), 45.15 (sensitivity=60.00%, specificity=75.00%) and 21.60 (sensitivity=60.00%, specificity=80.00%).Conclusion The pre-operative serum levels of mir-223, IL-6, TNF-α and IL-8 in HD children are significantly up-regulated and they are risk factors of postoperative enterocolitis.At the same time, the preoperative serum levels of mir-223, IL-6, TNF-α and IL-8 have a high predictive value for the postoperative occurrence of enterocolitis.Clinical interventions may adopted timely through detecting the relevant preoperative indicators for assessing the risk of postoperative HAEC and improving the quality-of-life of children.
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Memo
收稿日期:2019-12-16。
通讯作者:张大森,Email:guohong7070@qq.com