Su Jiahong,Li Shoulin.Role and treatment advances of renin-angiotensin system in children with vesicourethral dysfunction[J].Journal of Clinical Pediatric Surgery,,20():273-279.[doi:10.12260/lcxewkzz.2021.03.014]
Role and treatment advances of renin-angiotensin system in children with vesicourethral dysfunction
- CLC:
- R726.9;R694;R695
- Abstract:
- The clinical symptoms of vesicourethral dysfunction vary greatly in children.Sometimes the treatments are ineffective.Thus, various severe complications and even fatal kidney failure appears.The role of renin-angiotensin system (RAS),especially local RAS,has been well-known in inflammation and organ remodeling.RAS inhibitors (including ACEI & ARBs) and ACE2-Ang(1-7)-Mas axis,a newly discovered antagonistic axis,have the functions of relieving lower urinary tract symptoms and offering tissue protection.For exploring the possibility of local renin-angiotensin system in urinary tract as a new target for drug therapy of vesicourethral dysfunction and its related complications in children,this review focused upon the role of ACE-AngⅡ-AT1/ACE2-ang(1-7)-Mas axis in vesicourethral dysfunction as well as its complications.
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Memo
收稿日期:2020-03-24。
基金项目:深圳市医疗卫生三名工程(编号:SZSM201612013);深圳市卫生计生系统科研项目(编号:SZXJ2018045);国家自然科学基金联合基金项目重点支持项目(编号:U1904208)
通讯作者:李守林,Email:lishoulinsz@126.com