Liu Jingjing,Xiao Ting,Jiang Lidan,et al.Application of analgesia of intravenous ibuprofen for orthopedic children in PACU[J].Journal of Clinical Pediatric Surgery,,20():268-272,296.[doi:10.12260/lcxewkzz.2021.03.013]
Application of analgesia of intravenous ibuprofen for orthopedic children in PACU
- Keywords:
- Intravenous Ibuprofen; Anesthesia Analgesia; Treatment Outcome; Child
- CLC:
- R726.8;R614
- Abstract:
- Objective To observe the efficacy and safety of intravenous analgesia of ibuprofen versus tramadol in postanesthesia care unit (PACU) for orthopedic children under general anesthesia.Methods A total of 100 children aged 1 to 15 years with FLACC score ≥ 4 were randomly divided into ibuprofen (A,n=50) and tramadol (B,n=50) groups.Group A received a single dose of 10 mg/kg IV-ibuprofen while Group B a single dose of 2 mg/kg IV-tramadol.The profiles of efficacy and treatment-emergent adverse event (AE) were observed.Global evaluations were conducted for overall treatment efficacy before leaving PACU.Results The FLACC score of each group was significantly lower than that pre-dosing (P<0.001).The pain intensity difference (PAID) of Group A was greater than that of Group B and the inter-group difference was statistically significant (P=0.027).In terms of AE,Group A was slightly lower than Group B.However,the difference was not statistically significant (P=0.148).The percentage of rescue analgesia was (18%,9/50) for ibuprofen and (40%,20/50) for tramadol.And the difference was statistically significant (χ2=5.877,P=0.015).As for overall analgesic efficacy,the effective or efficacious percentage was (82%,41/50) for ibuprofen and (58%,29/50) for tramadol.And the difference was statistically significant (χ2=6.857,P=0.009).The most frequent AE was dizziness (n=11).No significant inter-group difference existed in vomiting,sedation,respiratory depression,fever or other aspects.Conclusion Intravenous ibuprofen is both safe and effective for relieving postoperative pain in children.An injection dose of 10 mg/kg is well-tolerated and produces better analgesic effect than tramadol 2 mg/kg.It is a safe option for immediate postoperative pain relief.
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Memo
收稿日期:2020-09-24。
基金项目:湖南省自然科学基金（编号：2018JJ2211）
通讯作者:屈双权,Email:qushuangquan1974@163.com