Zheng Dayou,Li Yanfang,Li Chuangye,et al.Comparison of metabolic differences between children with calcium oxalate stone and non-urolithiasis[J].Journal of Clinical Pediatric Surgery,,20():44-48.[doi:10.12260/lcxewkzz.2021.01.009]
Comparison of metabolic differences between children with calcium oxalate stone and non-urolithiasis
- Keywords:
- Calcium Oxalate; Metabolism; Calculi; Clild
- CLC:
- R726.8;R691.4
- Abstract:
- Objective To compare the indices of blood and 24-hour urine-related metabolites between children with calcium oxalate stone and non-urolithiasis.Methods From August 2016 to October 2018 at Hunan Children’s Hospital,this case-control study selected 75 children with calcium oxalate as case group and 75 non-urolithiasis counterparts of the same age/gender as control group.Blood and 24 hours urine biochemical results were measured and the differences of blood and 24 hours urine-related metabolic indices were compared between case and control groups.Results The excretions of 24 hours urine-related metabolites were compared:No significant inter-group difference existed in unit body weight urine volume,unit body surface area oxalic acid[310.5(228.4,445.6) mg/1.73 m2] or unit bodyweight total calcium[135.9(103.9,178.6) mg/L] [446.9(251.5,600.4) mg/1.73 m2,153.3(114.7,257.7) mg/L](Z=-2.795,Z=-2.020;P>0.05);the concentrations of unit body surface area citric acid and urinary citric acid in case group were lower than those in control group while the concentration of urinary oxalic acid was higher in case group than that in control group (Z=-3.024,P>0.05).No significant inter-group differences existed in blood concentrations of potassium,calcium,chlorine,urea nitrogen,creatinine or uric acid (P>0.05).Blood sodium in case group[139.3±2.6 mmol/L] was higher than that inontrol group[138.2±1.9 mmol/L] and the difference was statistically significant (t=2.851,P<0.05).Conclusion Urinary oxalic acid,urinary citrate and blood sodium concentrations may be correlated with the formation of calcium oxalate stone in children.However,further studies are required for elucidating the relationship between metabolite concentration and calcium oxalate stone.
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Memo
收稿日期:2020-05-15。
基金项目:湖南省自然科学基金（编号：2017JJ2139）
通讯作者:赵夭望,Email:yw508@sina.com