Yu Jiabin,Lu Hongting.Research advances of circular RNAs in common pediatric malignant solid tumors[J].Journal of Clinical Pediatric Surgery,,19():1012-1015,1031.[doi:10.3969/j.issn.1671-6353.2020.11.010]
Research advances of circular RNAs in common pediatric malignant solid tumors
- Keywords:
- circRNA; Malignant Tumors; Solid Tumors; Differential Expression; Child
- CLC:
- R726;R730.26
- Abstract:
- As one of the most important causes of mortality among children only after accidental death,pediatric malignant tumor has become a major factor endangering children’s health[1-2].Circular RNA (circRNA) is a class of non-coding RNA molecules.Unlike traditional linear RNA,circRNA molecules have a closed and stably expressed circular structure not liable to degradation by endonucleases.As demonstrated by recent studies,circRNA plays an important role in the occurrence,metastasis and invasion of malignant solid tumors in children.Thus it implied that circRNA may become a new therapeutic breakthrough for malignant solid tumors in children.This article reviews the latest research advances of circRNA in pediatric malignant solid tumors.
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Memo
收稿日期:2019-12-14。
基金项目:青岛市民生科技计划项目（编号：18—6—17—nsh）
通讯作者:鹿洪亭,Email:luhongting@126.com