Luo Haiyan,Li Shuangjie,Li Bixiang,et al.Diagnostic value of children with liver fibrosis by transient elastography[J].Journal of Clinical Pediatric Surgery,,19():481-485.[doi:10.3969/j.issn.1671-6353.2020.06.004]
Diagnostic value of children with liver fibrosis by transient elastography
- Keywords:
- Ultrasonography; Liver Cirrhosis/DI; Child
- CLC:
- R604;R364.3+2;R575.7;R725.7;R445.1
- Abstract:
- Objective To evaluate the diagnostic value of applying transient elastography for children with liver fibrosis.Methods Retrospective studies were conducted for 153 hospitalized children of chronic hepatitis B and biliary atresia admitted from January 1,2015 to December 31,2018 and from January 1,2016 to December 31,2018 respectively.The values of liver stiffness measurement (LSM) by transient elastography and their general profiles were collected.They were divided into liver fibrosis group (F≥1) and non-hepatic group (F=0); group with obvious liver fibrosis (F≥2) and group without obvious liver fibrosis (F<2); progressive liver fibrosis group (F≥3) and non-progressive liver fibrosis group (F<3); cirrhotic group (F=4) and non-cirrhotic group (F<4).Results The operating characteristic area under curve (AUC) of receiver with liver fibrosis diagnosed by transient elastography was 0.850,the optimal cut-off value 7.4 kpa and the sensitivity and the specificity 79.86% and 77.78% respectively.The AUC of children with obvious hepatic fibrosis was 0.864,the optimal cut-off value 9.2 kpa and the sensitivity and the specificity 70.43% and 84.21% respectively.The AUC of children with progressive hepatic fibrosis was 0.840,the optimal cut-off value 11.2 kpa and the sensitivity and the specificity 62.67% and 93.59% respectively.The AUC of children with cirrhosis was 0.894,the optimal cut-off value 13.3 kpa and the sensitivity and the specificity 70.83% and 91.47% respectively.Conclusion Transient elastography has an excellent application value in the diagnosis of different degrees of hepatic fibrosis in children.
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Memo
收稿日期:2020-03-03。
基金项目:国家自然科学基金（编号：8167969）；省属医院重点临床专科建设（编号：湘卫财务发[2019]4号）
通讯作者:李双杰,Email:Lesjie@vip.sina.com