Chen Zhixue,Dong Rui.Advances in the treatment of hepatoblastoma[J].Journal of Clinical Pediatric Surgery,,19():398-403.[doi:10.3969/j.issn.1671-6353.2020.05.005]
Advances in the treatment of hepatoblastoma
- Keywords:
- Liver Neoplasms; Therapy; Targeted Therapy; Immunotherapy
- CLC:
- R726;R735.7;R730.51
- Abstract:
- Hepatoblastoma (HB) is a type of embryonal tumor of high malignancy usually occurring in children under 3 years of age.Surgical resection is the preferred option for HB.Complete surgical resection means better prognosis for tumor.Due to its sensitivity to chemotherapy,it can be treated by chemotherapy,radiotherapy and other treatment means.Currently,the mainstream chemotherapy program is C5V.Liver transplantation can be used for refractory HB,and there have been successful cases of autologous liver transplantation.In addition,targeted therapies,such as targeted drugs targeting NK1R and PI3K/Akt pathway,have entered clinical trials,and immunotherapy is still in the development stage.
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Memo
收稿日期:2019-08-07。
通讯作者:董瑞,Email:rdong@fudan.edu.cn