Ge Liang,Zhan Jianghua.Relationship between liver fibrosis and native liver survival in infants with biliary atresia[J].Journal of Clinical Pediatric Surgery,,19():171-175.[doi:10.3969/j.issn.1671-6353.2020.02.016]
Relationship between liver fibrosis and native liver survival in infants with biliary atresia
- CLC:
- R575.7;R657.4+4;R726
- Abstract:
- Biliary atresia (BA) is one of the most serious hepatobiliary diseases during infancy.Kasai portoenterostomy has been a standard treatment for BA.However,its long-term postoperative survival of native liver is poor.Most children require liver transplantation for saving their lives.Liver fibrosis is one of the important influencing factors for native liver survival in BA children.The underlying mechanism is so complex as to involve a large variety of signaling pathways and cytokines.Imperfect biliary drainage and postoperative cholangitis may lead to liver fibrogenesis and even cirrhosis.For achieving long-term native liver survival,we should actively intervene to arrest the progression of liver fibrosis.
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Memo
收稿日期:2018-10-03。
基金项目:国家自然科学基金项目(编号:81570471);天津市卫生行业重点攻关项目(编号:14KG129)
通讯作者:詹江华,Email:zhanjianghuatj@163.com